Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake
Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake
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DOI：
10.2220/biomedres.31.231
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发表时间：
2010-08-01
影响因子：
1.2
通讯作者：
Ohnuki, Koichiro
中科院分区：
文献类型：
--
作者：
Nagano, Mayumi;Shimizu, Kuniyoshi;Ohnuki, Koichiro
猴头菌（Hericium erinaceus）是一种著名的食用菌，具有多种生物活性。特别是从其子实体中分离的hericenones和erinacines刺激神经生长因子（NGF）的合成，预期H。对脑功能和植物神经系统有一定的影响。本文研究了H.使用Kupperman月经指数（KMI）、流行病学研究中心抑郁量表（CES-D）、匹兹堡睡眠质量指数（PSQ 1）和无限期投诉指数（ICI），对猴头菌对更年期、抑郁、睡眠质量和无限期投诉的影响进行了研究。30名女性被随机分配到H。随机分为两组，每组10只，随机分为两组，即HE组和安慰剂组，并分别服用HE饼干和安慰剂饼干4周。HE摄入后CES-D和ICI评分均显著低于摄入前。在ICI的两个术语中，“无感觉”和“心悸”，HE组的每个平均得分均显著低于安慰剂组。“注意力集中”、“易怒”和“焦虑”倾向于低于安慰剂组。我们的研究结果表明，HE摄入量有可能减少抑郁和焦虑，这些结果表明，从神经生长因子增强作用的H不同的机制。刺猬。
Hericium erinaceus, a well known edible mashroom, has numerous biological activities. Especially hericenones and erinacines isolated from its fruiting body stimulate nerve growth factor (NGF) synthesis, which expects H. erinaceus to have some effects on brain functions and autonomic nervous system. Herein, we investigated the clinical effects of H. erinaceus on menopause, depression, sleep quality and indefinite complaints, using the Kupperman Menopausal Index (KMI), the Center for Epidemiologic Studies Depression Scale (CES-D), the Pittsburgh Sleep Quality Index (PSQ1), and the Indefinite Complaints Index (ICI). Thirty females were randomly assigned to either the H. erinaceus (HE) group or the placebo group and took HE cookies or placebo cookies for 4 weeks. Each of the CES-D and the ICI score after the HE intake was significantly lower than that before. In two terms of the ICI, "insentive" and "palpitation", each of the mean score of the HE group was significantly lower than the placebo group. "Concentration", "irritating" and "anxious" tended to be lower than the placebo group. Our results show that HE intake has the possibility to reduce depression and anxiety and these results suggest a different mechanism from NGF-enhancing action of H. erinaceus.