Diagnostic value of microRNA panel in endometrial cancer: A systematic review.
Diagnostic value of microRNA panel in endometrial cancer: A systematic review.
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DOI：
10.18632/oncotarget.27601
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发表时间：
2020-05-26
期刊：
影响因子：
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通讯作者：
Galaal, Khadra
中科院分区：
文献类型：
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作者：
Donkers, Hannah;Bekkers, Ruud;Galaal, Khadra
目的：我们进行了一项系统综述，以评估mirna检测子宫内膜癌的总体诊断准确性。材料和方法：系统检索Medline、Embase、Cinahl和Cochrane对照试验注册库，以确定报道miRNA在EC患者中的诊断价值的研究。其中包括观察诊断为子宫内膜癌的女性miRNA表达的诊断性研究。两位审稿人独立选择研究并使用诊断准确性研究质量评估2 （QUADAS-2）评分系统评估研究质量。完成数据提取，并使用投票计数策略对mirna进行排序。结果：纳入26项研究，共1,400例EC患者报告了106种差异表达的mirna。最常发现的上调miRNA是miR-205，其次是miR-200c、-223、-182、-183和-200a。此外，miR-135b、miR-429、miR-141和miR-200b也频繁上调。关于下调mirna的共识较少。结论：mirna在子宫内膜癌诊断中具有很好的生物标志物潜力，尤其是miR-205、miR-200家族和miR-135b、-182、-183和-223。然而，没有足够的高质量数据来得出确凿的结论。需要更多的研究来验证这些mirna在更大规模研究中的诊断潜力。此外，尿液作为一种非侵入性生物流体的潜力应该进行更详细的研究。
PURPOSE: We conducted a systematic review to evaluate the overall diagnostic accuracy of miRNAs in detecting endometrial cancer.MATERIALS AND METHODS: A systematic search of Medline, Embase, Cinahl and the Cochrane Controlled Register of Trials was performed to identify studies reporting on the diagnostic value of miRNA in EC patients. Included were diagnostic studies looking at miRNA expression in women diagnosed with endometrial cancer. Two reviewers independently selected studies and assessed quality of studies using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) score system. Data extraction was completed and the vote-counting strategy was used to rank miRNAs.RESULTS: 26 studies were included with a total number of 1,400 EC patients reporting on 106 differentially expressed miRNAs. The most frequently found up-regulated miRNA was miR-205 followed by miR-200c, -223, -182, -183 and -200a. In addition, miR-135b, miR-429, miR-141 and miR-200b were also frequently up-regulated. There was less consensus on down-regulated miRNAs.CONCLUSIONS: miRNAs yield a promising diagnostic biomarker potential in endometrial cancer, especially miR-205, the miR-200 family and miR-135b, -182, -183 and -223. However, no sufficient high quality data are available to draw hard conclusions. More research is needed to validate the diagnostic potential of these miRNAs in larger studies. In addition, the potential of urine as a non-invasive biofluid should be investigated in more detail.