Evidence of qualitatively altered nociception in patients with fibromyalgia
Evidence of qualitatively altered nociception in patients with fibromyalgia
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DOI：
10.1002/art.1780400114
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发表时间：
1997-01-01
影响因子：
--
通讯作者：
Olesen, J
中科院分区：
文献类型：
--
作者：
Bendtsen, L;Norregaard, J;Olesen, J
Objective.目的：探讨纤维肌痛患者压痛肌的疼痛感觉。对25例女性纤维肌痛患者和25例健康女性进行了检查，用7种不同的压力强度触诊高度压痛的肌肉和大体正常的肌肉，然后用视觉模拟量表记录受试者对诱发疼痛的反应，检查者对每个受试者的反应不知情。对于正常肌肉记录的压力与疼痛的刺激-反应函数由幂函数很好地描述，对于高度柔软的肌肉，刺激-反应函数向较低的压力移位，更重要的是，它是线性的，即，与正常肌肉有质的不同。这项研究表明，纤维肌痛患者的伤害性感受发生了质的改变，这与最近在其他肌肉压痛患者中的发现一致。数据强烈表明，纤维肌痛性疼痛至少部分是由于异常的中枢疼痛机制。
Objective. To investigate the perception of pain in tender muscles of patients with fibromyalgia.Methods. Twenty-five women with fibromyalgia and 25 healthy women were examined, Seven different pressure intensities were used to palpate a highly tender muscle and a largely normal muscle, Subjects then recorded their response to induced pain on a visual analog scale, The examiner was blinded to each subject's response.Results. The stimulus-response function for pressure versus pain recorded for normal muscle was well described by a power function, For highly tender muscle, the stimulus-response function was displaced toward lower pressures and, more importantly, it was linear, i.e., qualitatively different from that of normal muscle.Conclusion. This study demonstrates that nociception is qualitatively altered in patients with fibromyalgia, which is consistent with recent findings in other patients with tender muscles, The data strongly indicate that fibromyalgic pain, at least in part, is due to aberrant central pain mechanisms.