Increased risk of head tremor in women with essential tremor: Longitudinal data from the Rochester epidemiology project
Increased risk of head tremor in women with essential tremor: Longitudinal data from the Rochester epidemiology project
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DOI：
10.1002/mds.20096
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发表时间：
2004-05-01
影响因子：
8.6
通讯作者：
Louis, ED
中科院分区：
文献类型：
--
作者：
Hardesty, DE;Maraganore, DM;Louis, ED
在一项对北方曼哈顿社区的横断面研究中。患有特发性震颤（ET）的女性比男性更容易发生头部震颤。在该研究中，患者在一个时间点被观察，而不是纵向随访。头部震颤通常发生在手臂震颤之后，因此ET患者的头部震颤可能与随访时间有关。在利用罗切斯特流行病学项目的第二项流行病学研究中，对ET受试者进行了从疾病诊断到死亡的随访，我们确定了女性贷方和头部震颤之间是否存在关联。我们利用罗切斯特流行病学项目的记录链接系统来识别ET病例。由专门研究运动障碍的神经科医生审查记录并提取临床数据。第二位神经科医生审查了记录的子样本。ET 107例，女性69例。从ET诊断到死亡随访10.1 ± 9.1年。37例（53.6%）女性和5例（13.2%）男性患者存在头部震颤（比值比[OR] 7.6，95%置信区间[CI] = 2.7-21.9，P < 0.001）。在多元线性回归分析中，女性仍然处于与疾病持续时间无关的头部震颤高风险（OR = 6.5，95%CI = 2.2-19.0，P = 0.001）。我们在这项纵向流行病学研究中发现，患有ET的女性在疾病过程中发生头部震颤的可能性是男性的六倍。性别和头部震颤之间的关联，现在已经在几项研究中得到证实，其原因尚不清楚，但它可能反映了大脑内疾病病理分布的性别差异。(C)2004年，《运动障碍协会》。
In one cross-sectional study of a community in northern Manhattan. women with essential tremor (ET) were more likely to have head tremor than were men. In that study, patients were seen at one point in time, rather than followed longitudinally. Head tremor often develops after arm tremor, and its appearance in patients with ET may therefore be a function of duration Of follow-up. In a second epidemiological Study utilizing the Rochester Epidemiology Project, in which ET Subjects were followed from disease diagnosis to death, we determined whether there was an association between female lender and head tremor. We utilized the records-linkage system of the Rochester Epidemiology Project to identify ET cases. Records were reviewed and clinical data abstracted by a neurologist specializing in movement disorders. A second neurologist reviewed a subsample of records. There were 107 ET cases (69 women. 38 men) followed for 10.1 +/- 9.1 years from ET diagnosis to death. Head tremor was present in 37 (53.6%) women and 5 (13.2%) men (odds ratio [OR] 7.6, 95% confidence interval [CI] = 2.7-21.9, P < 0.001). In a multivariate linear regression analysis, women remained at high risk for head tremor (OR = 6.5, 95% CI = 2.2-19.0, P = 0.001) independent of disease duration. We found in this longitudinal epiemiological study that women with ET were six times more likely to develop head tremor over the course of their illness than were men. The reason for the association between gender and head tremor, which has now been demonstrated in several studies, is not known, but it could reflect gender differences in the distribution of disease pathology within the brain. (C) 2004 Movement Disorder Society.