Abnormally high plasma levels of vitamin B6 in children with autism not taking supplements compared to controls not taking supplements
Abnormally high plasma levels of vitamin B6 in children with autism not taking supplements compared to controls not taking supplements
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DOI：
10.1089/acm.2006.12.59
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发表时间：
2006-01-01
影响因子：
2.6
通讯作者：
Audhya, T
中科院分区：
文献类型：
--
作者：
Adams, JB;George, F;Audhya, T
背景资料：有许多关于高剂量补充维生素136对儿童和成人自闭症患者的影响的研究，除了一个报道之外，所有的研究都有益处。目的：本研究的目的是通过测量未补充维生素136的自闭症谱系障碍儿童与未补充维生素136的对照受试者相比血浆中总维生素B-6的水平，研究维生素B-6治疗的生化基础。参与者：自闭症谱系障碍儿童（n = 35，年龄3-9岁）和无关的典型儿童（n = 11，年龄6-9岁），所有来自亚利桑那州，进行了研究。(This包括我们之前研究中24名自闭症儿童的数据。方法学：一个微生物测定被用来测量总维生素136（包括磷酸化和非磷酸化形式）的水平，在一个盲fashion.Results：自闭症儿童有75%的总维生素B-6水平高于对照组（中位数为56与32纳克/毫升，分别为p = 0.00002）。大多数自闭症儿童（77%）的水平比对照组的中位数高出2个标准差。自闭症女孩（n = 5）也有升高的水平（平均值为54.6 ng/mL，中位数为60 ng/mL）。讨论：这些结果与以前的研究发现：（1）吡哆醛激酶有一个非常低的活动在自闭症儿童和（2）吡哆醛5磷酸（PLP）水平异常低，在自闭症儿童。因此，它似乎是低转化率的吡哆醛和吡哆醇PLP的结果在低水平的PLP，这是积极的辅因子为113已知的酶反应，包括许多关键的neuronaltransmitters.Conclusions的形成：总维生素B-6是异常高的自闭症，与以前的报告的一个受损的吡哆醛激酶的吡哆醇和吡哆醇PLP的转换一致。这可能解释了许多已发表的关于高剂量维生素B-6补充剂对一些自闭症儿童和成人的益处的研究。
Background: There have been many studies of the effect of high-dose supplementation of vitamin 136 on children and adults with autism, with all but one reporting benefits.Objective: The aim of this study was to investigate the biochemical basis for vitamin B-6 therapy by measuring the level of total vitamin B-6 in the plasma of unsupplemented children with autism spectrum disorder compared to unsupplemented control subjects.Participants: Children with autism spectrum disorders (n = 35, age 3-9 years) and unrelated typical children (n = 11, age 6-9 years), all from Arizona, were studied. (This includes the data from 24 children with autism from our previous study.)Methodology: A microbiologic assay was used to measure the level of total vitamin 136 (including phosphorylated and unphosphorylated forms), in a blinded fashion.Results: Children with autism had a 75% higher level of total vitamin B-6 than the controls (medians of 56 versus 32 ng/mL, respectively, p = 0.00002). Most of the autistic children (77%) had levels that were more than 2 standard deviations above the median value of the controls. The autistic girls (n = 5) also had elevated levels (mean of 54.6 ng/mL, median of 60 ng/mL).Discussion: These results are consistent with previous studies that found that: (1) pyridoxal kinase had a very low activity in children with autism and (2) pyridoxal 5 phosphate (PLP) levels are unusually low in children with autism. Thus, it appears that the low conversion of pyridoxal and pyridoxine to PLP results in low levels of PLP, which is the active cofactor for 113 known enymatic reactions, including the formation of many key neurotransmitters.Conclusions: Total vitamin B-6 is abnormally high in autism, consistent with previous reports of an impaired pyridoxal kinase for the conversion of pyridoxine and pyridoxal to PLP. This may explain the many published studies of benefits of high-dose vitamin B-6 supplementation in some children and adults with autism.