Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplementation with antioxidants and essential fatty acids
Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplementation with antioxidants and essential fatty acids
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DOI：
10.2147/cia.s43191
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发表时间：
2013-01-01
影响因子：
3.6
通讯作者：
Benitez-del-Castillo, Javier
中科院分区：
文献类型：
--
作者：
Galbis-Estrada, Carmen;Pinazo-Duran, Maria D.;Benitez-del-Castillo, Javier
背景：青光眼和干眼症是常见的合并症。必需多不饱和脂肪酸的抗氧化和抗炎特性与眼病的关系已被广泛研究。目的：我们的目的是确定口服抗氧化剂和必需多不饱和脂肪酸联合制剂对DEDs或原发性开角型青光眼（POAG）患者泪液中细胞因子和趋化因子表达的影响。方法：将97名参与者分为3组：(1)非重度DEDs (DEDG),(2)非晚期POAG (POAGG),(3)健康对照。这些组随机分为两个亚组：一个组每天服用抗氧化剂和必需多不饱和脂肪酸补充剂（两粒），持续3个月（+S），另一个组不服用（-NS）。参与者接受了访谈和眼科检查。反射性泪液中特异性细胞因子和趋化因子的浓度采用多通道颗粒流式细胞术测定。数据采用SPSS 15.0版本进行统计学分析。结果：DEDG患者与POAGG患者泪液中粒细胞-巨噬细胞集落刺激因子（P = 0.008）、肿瘤坏死因子a （P = 0.005）、血管内皮生长因子（P = 0.038）、白细胞介素-4 （P = 0.030）、白细胞介素-6 （P = 0.044）的表达差异有统计学意义。DEDG +S组和POAGG +S组的干眼主要体征和症状，如干涩、灼烧、畏光、眼沉、视力模糊，以及睫毛、头发、指甲、皮肤的积极变化，均较未补充的患者有明显改善。结论：炎症生物标志物在青光眼泪液中有差异表达，但在补充抗氧化剂/必需多不饱和脂肪酸后差异发生变化。慢性滴注降压眼药水必须考虑纳入青光眼治疗标准。
Background: Glaucoma and dry eye disorders (DEDs) are frequent comorbidities. The antioxidant and anti-inflammatory properties of essential polyunsaturated fatty acids have been extensively studied in relation to eye diseases.Objective: Our objective was to determine the effects of oral supplementation with a combined formulation of antioxidants and essential polyunsaturated fatty acids on expression of cytokines and chemokines in tears from patients with DEDs or primary open-angle glaucoma (POAG).Methods: Participants (n = 97) were distributed into three groups: (1) individuals with nonsevere DEDs (DEDG), (2) individuals with nonadvanced POAG (POAGG), and (3) healthy controls. These groups were randomized into two subgroups: one received a daily antioxidant and essential polyunsaturated fatty acid supplement (two pills) for 3 months (+S), and the other did not (-NS). Participants were interviewed and ophthalmologically examined. Concentrations of specific cytokines and chemokines in reflex tears were determined by multiplexed particle-based flow cytometry. The data were analyzed statistically (SPSS version 15.0).Results: Comparison of the results from the DEDG and POAGG patients showed significant differences in tear expression of granulocyte-macrophage colony-stimulating factor (P = 0.008), tumor necrosis factor a (P = 0.005), vascular endothelial growth factor (P = 0.038), interleukin-4 (P = 0.030), and interleukin-6 (P = 0.044). The main signs and symptoms of dry eyes such as dryness, burning, photophobia, eye heaviness, and blurred vision, as well as positive changes in eyelashes, hair, nails and skin, were significantly improved in DEDG +S and POAGG +S patients relative to unsupplemented patients.Conclusion: Inflammation biomarkers were differentially expressed in glaucomatous tears, but the differences changed upon antioxidant/essential polyunsaturated fatty acid supplementation. Chronic instillation of antihypertensive eye drops must be considered for integrating protocols to glaucoma standards of care.