The mouse genome
The mouse genome
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DOI：
10.1101/gr.3728305
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发表时间：
2005-12-01
期刊：
影响因子：
7
通讯作者：
Guénet, JL
中科院分区：
文献类型：
--
作者：
Guénet, JL
自遗传学早期以来，家鼠一直被用作特权模式生物，用这种小型哺乳动物进行的大量实验经常有助于丰富我们对哺乳动物生物学和病理学的知识，从胚胎发育到代谢性疾病、组织相容性、免疫学、行为和癌症。在过去的二十年里，已经开展了一些大规模、综合和协调一致的项目，这些项目可能会开启该物种遗传学的新纪元。基因组测序可能是最重要的项目，这将使研究人员能够与其他哺乳动物进行比较，并确定进化所保守的区域，但许多其他倡议，如与突变表型的全面和标准化表型相关的大规模点突变或染色体突变的产生，将有助于对小鼠基因组中类似于25,000个基因的注释。同样，作为测序的另一个结果，许多单核苷酸多态的发现以及新工具和资源的开发，如合作杂交，将有助于现代数量遗传学的发展。很明显，在过去的10-15年里，老鼠的遗传学发生了巨大的变化，它的未来看起来很有希望。
The house mouse has been used as a privileged model organism since the early days of genetics, and the numerous experiments made with this small mammal have regularly contributed to enrich Our knowledge of mammalian biology and pathology, ranging from embryonic development to metabolic disease, histocompatibility, immunology, behavior, and cancer. Over the past two decades, a number of large-scale integrated and concerted projects have been undertaken that will probably open a new era in the genetics of the species. The sequencing of the genome, which will allow researchers to make comparisons with other mammals and identify regions conserved by evolution, is probably the most important project, but many other initiatives, such as the massive production of point or chromosomal mutations associated with comprehensive and standardized phenotyping of the mutant phenotypes, will help annotation of the similar to 25,000 genes packed in the mouse genome. In the same way, and as another consequence of the sequencing, the discovery of many single nucleotide polymorphisms and the development of new tools and resources, like the Collaborative Cross, will contribute to the development of modern quantitative genetics. It is clear that mouse genetics has changed dramatically over the last 10-15 years and its future looks promising,.