Tailoring of Proteostasis Networks with Heat Shock Factors
Tailoring of Proteostasis Networks with Heat Shock Factors
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DOI：
10.1101/cshperspect.a034066
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发表时间：
2019-04-01
影响因子：
7.2
通讯作者：
Sistonen, Lea
中科院分区：
文献类型：
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作者：
Joutsen, Jenny;Sistonen, Lea
热休克因子（Heat shock factors，HSFs）是热休克反应的主要转录调节因子，是维持细胞蛋白质稳态不可或缺的因子。HSFs通过不同的遗传程序介导其保护功能，这些遗传程序由编码分子伴侣的基因和其他对细胞存活至关重要的基因组成。用于定制HSF驱动的蛋白质稳定网络的机制尚未完全理解，但它们可能包括遗传和蛋白质组决定因素的不同组合。在这篇综述中，我们强调了从细胞应激反应到各种生理和病理过程的多功能HSF介导的细胞功能，并强调了在过去十年中在HSF研究领域取得的关键进展。
Heat shock factors (HSFs) are the main transcriptional regulators of the heat shock response and indispensable for maintaining cellular proteostasis. HSFs mediate their protective functions through diverse genetic programs, which are composed of genes encoding molecular chaperones and other genes crucial for cell survival. The mechanisms that are used to tailor HSF-driven proteostasis networks are not yet completely understood, but they likely comprise from distinct combinations of both genetic and proteomic determinants. In this review, we highlight the versatile HSF-mediated cellular functions that extend from cellular stress responses to various physiological and pathological processes, and we underline the key advancements that have been achieved in the field of HSF research during the last decade.