Association of chlorhexidine and fluoride for plaque control and white spot lesion remineralization in primary dentition
Association of chlorhexidine and fluoride for plaque control and white spot lesion remineralization in primary dentition
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DOI：
10.1111/j.1365-263x.2008.00914.x
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发表时间：
2008-11-01
影响因子：
3.8
通讯作者：
De Toledo, Orlando Ayrton
中科院分区：
文献类型：
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作者：
De Amorim, Rodrigo Guedes;Leal, Soraya Coelho;De Toledo, Orlando Ayrton
背景牙菌斑控制和龋齿阻止仍然是牙科医生面临的挑战。本研究旨在评价氯己定涂膜与氟涂膜联合使用对乳牙期可见菌斑指数（VPI）和白色斑（WS）矿化的影响。将80名3-5岁患龋儿童随机分为4组。第1组在4周内每周接受洗必泰清漆应用。第2组在4周内每周接受氟化物涂膜应用。第3组在4周内交替应用洗必泰和氟化物涂膜。第4组为对照组（不使用任何类型的防龋剂）。1个月后，组间VPI和WS的平均化差异无统计学意义。然而，3个月的随访表明，第3组（氯己定+氟化物）显示了更好的结果，无论是VPI和WS的再矿化。3个月后，洗必泰和氟化物涂膜联合应用对菌斑和早期龋再矿化的作用优于单独应用。
Background. Plaque control and caries arrest still remain a challenge for dentists.Objective. This study was conducted to assess the effect of the combined use of chlorhexidine varnish and fluoride varnish on the visible plaque index (VPI) and white spot lesion (WS) remineralization in primary dentition.Methods. A total of 80 caries-active preschool children (3-5 years) were randomly divided into four groups. Group 1 received a chlorhexidine varnish application every week during 4 weeks. Group 2 received a fluoride varnish application every week during 4 weeks. Group 3 received alternated applications of chlorhexidine and fluoride varnish during 4 weeks. Group 4 served as control (without any type of cariostatic agent).Results. There was no statistically significant difference in the VPI and WS remineralization among the groups after 1 month. However, 3 months follow-up demonstrated that group 3 (chlorhexidine + fluoride) showed significantly better results for both VPI and WS remineralization.Conclusion. The combined application of chlorhexidine and fluoride varnishes is more effective on plaque and remineralization of incipient caries after 3 months than the same agents applied separately.