Acid base homeostasis and serum bicarbonate concentration in syndrome of inappropriate anti-diuretic hormone secretion (SIADH) with hyponatremia.
Acid base homeostasis and serum bicarbonate concentration in syndrome of inappropriate anti-diuretic hormone secretion (SIADH) with hyponatremia.
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DOI：
10.3389/fendo.2023.1321338
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发表时间：
2023
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
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ADH分泌不当综合征（SIADH）表现为由一系列条件引起的过量ADH释放；包括肺炎、脑肿瘤、某些肺癌和下丘脑疾病。它表现为血液中钠和氯浓度的显著降低。然而，检查酸碱状态的报告表明正常的血清碳酸氢盐浓度和全身酸碱稳态。酸碱平衡中没有异常的机制仍然是推测性的。本文综述了肾脏分子生理学的最新进展，为维持生理范围内的酸碱状态和血清碳酸氢盐提供答案。
The Syndrome of Inappropriate ADH secretion (SIADH) presents with excess ADH release caused by a range of conditions; including pneumonia, brain tumors, certain lung cancers, and diseases of the hypothalamus. It presents with significant reduction in both sodium and chloride concentrations in the blood. However, reports examining the acid base status indicate a normal serum bicarbonate concentration and systemic acid base homeostasis. The mechanisms for the absence of abnormalities in acid base homeostasis remain speculative. This mini review is highlighting the recent advances in renal molecular physiology to provide answers for the maintenance of acid base status and serum bicarbonate in a physiological range.