P300 amplitudes vary inversely with continuum of risk in first degree male relatives of alcoholics
P300 amplitudes vary inversely with continuum of risk in first degree male relatives of alcoholics
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DOI：
10.1097/00041444-199524000-00001
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发表时间：
1995-12-01
影响因子：
0.9
通讯作者：
Channabasavanna, SM
中科院分区：
文献类型：
--
作者：
Benegal, V;Jain, S;Channabasavanna, SM
酗酒者的一级亲属表现出显著降低的P300振幅。这种现象被认为是酗酒的脆弱性标志。酗酒者的家庭负担较高和早发性酒精中毒的亲属患酒精中毒的风险更大。高风险人群可以包括通过家族史和/或酗酒发作时的年龄区分的亚型，具有不同的风险，可以根据脆弱性标志物的表达来测量。四组酒精幼稚的儿子/酗酒者的男性兄弟姐妹（n = 64）进行了研究。这些群体是根据两个定义特征的排列而构建的：高家庭负担（两个或更多一级酗酒亲属）和亲属中早发性酒精依赖（25岁之前）。听觉范式中P300振幅的比较显示出显著的组间差异以及从高负荷早发组（HR 1）到低负荷迟发组（HR 4）的振幅的逐渐增加/正常化，后者与单独的（对照）正常组没有区别。P300潜伏期各组间差异无统计学意义。我们的结论是，P300的振幅与假定的连续风险在那些高风险发展为酗酒。
First degree relatives of alcoholics show significantly reduced P300 amplitudes. This phenomenon is thought to be a vulnerability marker of alcoholism. Relatives of alcoholics with higher family loading and early onset alcoholism are at greater risk for developing alcoholism. The high risk population may comprise subtypes differentiated by family history and/or age at onset of alcoholism, with differing risks, measurable in terms of the expression of the vulnerability marker. Four groups of alcohol-naive sons/male siblings of alcoholics (n = 64) were studied. The groups were constructed on the permutation of two defining characteristics: high family loading (two or more first degree alcoholic relatives) and early onset alcohol dependence (before 25 years) in the relatives. Comparison of P300 amplitude in an auditory paradigm showed significant inter-group differences as well as progressive increase/normalization of amplitudes from the high loading-early onset group (HR1) to the low loading-late onset group (HR4), with the latter being indistinguishable from a separate group of (control) normals. There were no significant differences of P300 latency among the groups. We conclude that P300 amplitudes vary inversely with the presumed continuum of risk in those at high risk for developing alcoholism.