Unique lipid A modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis
Unique lipid A modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis
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DOI：
10.1086/521367
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发表时间：
2007-10-01
影响因子：
6.4
通讯作者：
Miller, Samuel I.
中科院分区：
文献类型：
--
作者：
Ernst, Robert K.;Moskowitz, Samuel M.;Miller, Samuel I.
类脂A的三个结构特征（棕榈酸酯[C16脂肪酸]的添加、氨基阿拉伯糖[带正电荷的氨基糖残基]的添加和3-羟基癸酸酯[3-OH C10脂肪酸]的保留）测定了来自囊性纤维化患者的铜绿假单胞菌分离株（CF; n = 86），来自环境（n = 13），和来自其他条件的患者（n = 13）。在铜绿假单胞菌CF分离株中，100%的脂质A含有棕榈酸酯，24.6%含有氨基阿拉伯糖，33.3%保留3-羟基癸酸酯。来自环境或患有其他疾病的患者的分离株均未显示这些修饰。这些结果表明，临床铜绿假单胞菌CF分离株中发生了独特的脂质A修饰。
Three structural features of lipid A ( addition of palmitate [C16 fatty acid], addition of aminoarabinose [ positively charged amino sugar residue], and retention of 3-hydroxydecanoate [3-OH C10 fatty acid]) were determined for Pseudomonas aeruginosa isolates from patients with cystic fibrosis (CF; n = 86), from the environment (n = 13), and from patients with other conditions (n = 13). Among P. aeruginosa CF isolates, 100% had lipid A with palmitate, 24.6% with aminoarabinose, and 33.3% retained 3- hydroxydecanoate. None of the isolates from the environment or from patients with other conditions displayed these modifications. These results indicate that unique lipid A modifications occur in clinical P. aeruginosa CF isolates.