Synthesis of Four Stereoisomers of Carbocyclic 5′-NOR D4A and Evaluation of Their Triphosphates as Substrates for DNA Polymerases
Synthesis of Four Stereoisomers of Carbocyclic 5′-NOR D4A and Evaluation of Their Triphosphates as Substrates for DNA Polymerases
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碳环 5-NOR D4A 四种立体异构体的合成及其三磷酸酯作为 DNA 聚合酶底物的评价
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
M. Janta
中科院分区：
文献类型：
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作者：
N. Dyatkina;D. Semizarov;L. Victorova;A. Krayevsky;F. Theil;M. Janta
摘要以常见的对映体纯的烯丙基单乙酸酯1为原料，合成了4种对映体纯的5′-去甲碳环核苷4 b、ent-4 b、ent-10和ent-10。将核苷类似物转化为相应的三磷酸衍生物6、ent-6、12和ent-12。评价了后者对不同DNA聚合酶的底物性质。
Abstract A method was developed for synthesis of the four stereoisomeric enantiomerically pure 5′-nor carbocyclic nucleosides 4b, ent-4b, 10 and ent-10 starting from the common enantiomerically pure allylic monoacetate 1. Nucleoside analogues were converted to the corresponding triphosphate derivatives 6, ent-6, 12, and ent-12. The substrate properties of the latters towards different DNA polymerases were evaluated.