Hippocampal volume and memory performance in children with perinatal stroke.
Hippocampal volume and memory performance in children with perinatal stroke.
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DOI：
10.1016/j.pediatrneurol.2013.08.029
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发表时间：
2014-01
影响因子：
3.8
通讯作者：
Trauner DA
中科院分区：
文献类型：
--
作者：
Gold JJ;Trauner DA
儿科神经科医生和儿科医生经常被要求对围产期脑损伤后的认知结果（包括可能的记忆和学习结果）进行详细说明;然而，相对较少的数据可以做出准确的预测。此外，虽然脑损伤对海马体积和记忆表现的影响已在成人中进行了广泛研究，但在儿童中的研究却很少。我们测量了27名围产期中风儿童和19名对照组的海马体积，并测量了他们在标准化语言和非语言记忆测试中的表现。(i)作为一个群体，与对照组相比，围产期中风的儿童有较小的左，右前动脉。(ii)单独来看，与对照组相比，围产期卒中儿童表现出3种结果之一：无海马丢失、单侧海马丢失或双侧海马体积丢失。(iii)海马体积与围产期中风组的记忆测试表现呈负相关，较小的左右海马体积分别与较差的语言和非语言记忆测试表现相关。(iv)癫痫发作在确定围产期卒中患者记忆缺陷的存在和海马体积减少的程度方面起着重要作用。这些发现支持了这样一种观点，即在发育中的大脑中，左、右大脑半球分别优先支持语言记忆和非语言记忆，这在成人文献中是一致的，但在儿科文献中是一个争论的主题。这是第一项报告围产期中风引起的局灶性脑损伤的儿童海马体体积减少和陈述性记忆某些方面的损害的工作。
Pediatric neurologists and neonatologists are often asked to prognosticate about cognitive outcome after perinatal brain injury (including likely memory and learning outcomes); however, relatively little data exists upon which accurate predictions can be made. Further, while the consequences of brain injury on hippocampal volume and memory performance have been studied extensively in adults, little work has been done in children. We measured the volume of the hippocampus in 27 children with perinatal stroke and 19 controls, and measured their performance on standardized verbal and non-verbal memory tests. (i) As a group, children with perinatal stroke had smaller left and right hippocampi compared to controls. (ii) Individually, children with perinatal stroke demonstrated one of 3 findings: no hippocampal loss, unilateral hippocampal loss, or bilateral hippocampal volume loss compared to controls. (iii) Hippocampal volume inversely correlated with memory test performance in the perinatal stroke group, with smaller left and right hippocampal volumes related to poorer verbal and non-verbal memory test performance, respectively. (iv) Seizures played a significant role in determining the presence of memory deficit and extent of hippocampal volume reduction in patients with perinatal stroke. These findings support the view that, in the developing brain, the left and right hippocampi preferentially support verbal and non-verbal memory respectively, a consistent finding in the adult literature but a subject of debate in the pediatric literature. This is the first work to report that children with focal brain injury incurred from perinatal stroke have volume reduction in the hippocampus and impairments in certain aspects of declarative memory.
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