Impact of untreated bednets on prevalence of Wuchereria bancrofti transmitted by Anopheles farauti in Papua New Guinea
Impact of untreated bednets on prevalence of Wuchereria bancrofti transmitted by Anopheles farauti in Papua New Guinea
复制标题
DOI：
10.1046/j.0269-283x.2002.00352.x
复制
发表时间：
2002-03-01
影响因子：
1.9
通讯作者：
Kazura, JW
中科院分区：
文献类型：
--
作者：
Bockarie, MJ;Tavul, L;Kazura, JW
尽管越来越多的证据表明，驱虫蚊帐在各种流行病条件下降低了疟疾发病率和死亡率，但其对淋巴丝虫病感染和疾病的价值尚未确定。在巴布亚新几内亚的Bagabag岛调查了未经处理的蚊帐对班氏吴策线虫（Cobbold）（线虫纲：丝虫总科）感染和疾病流行的影响，在那里疟疾和丝虫病都是由同一媒介蚊--点状按蚊Donitz群（双翅目：蚊科）传播的。进行了全社区调查，记录了包括蚊帐使用情况在内的人口特征。进行体腔积水和淋巴水肿的体格检查，并对血液样本进行丝虫和疟疾寄生虫评估。采用整夜着陆捕获法对蚊子进行采样，并单独解剖以确定W。bancrofti感染和感染率。居民蚊帐使用率为61%，使用者的平均年龄（25.6岁）与非使用者（22.5岁）相似。法氏按蚊Laveran是唯一发现含有丝虫幼虫的物种：2.7%感染（所有阶段），0.5%感染（L3）。整体W。班氏微丝蚴血症率和抗原血症率分别为28.5%和53.1%。蚊帐使用者W.班氏微丝蚴血症、抗原血症和体腔积水的发生率高于非使用者。相比之下，未经处理的蚊帐对恶性疟原虫和间日疟原虫感染的流行率和严重程度没有影响。即使考虑到年龄、地点和性别等混杂因素，蚊帐使用对微丝蚴血症和抗原血症率的影响仍然很大，这表明未经处理的蚊帐可以预防班氏TV感染。
Despite the growing, evidence that insecticide-treated mosquito nets reduce malaria morbidity and mortality in a variety of epidemiological conditions, their value against lymphatic filariasis infection and disease is yet to be established. The impact of untreated bednets on the prevalence of Wuchereria bancrofti (Cobbold) (Nematoda: Filarioidea) infection and disease was investigated on Bagabag island in Papua New Guinea, where both malaria and filariasis are transmitted by the same vector mosquitoes of the Anopheles punctulatus Donitz group (Diptera: Culicidae). Community-wide surveys were conducted recording demographic characteristics including bednet usage. Physical examinations for hydrocoele and lymphoedema were performed and blood samples assessed for filarial and malaria parasites. Mosquitoes were sampled using the all-night landing catch method and individually dissected to determine W. bancrofti infection and infective rates. Bednet usage among residents was 61% and the mean age of users (25.6 years) was similar to non-users (22.5 years). Anopheles farauti Laveran was the only species were found to contain filarial larvae: 2.7% infected (all stages), 0.5% infective (L3). The overall W. bancrofti microfilaraemia and anti-genaemia rates were 28.5% and 53.1%, respectively. Bednet users had lower prevalence of W. bancrofti microfilaraemia, antigenaemia and hydrocoele rates than non-users. In comparison, untreated bednets had no effect on the prevalence and intensity of Plasmodium falciparum and P. vivax infections. The impact of bednet usage on rates of microfilaraemia and antigenaemia remained significant even when confounding factors such as age, location and sex were taken into account, suggesting that untreated bednets protect against TV bancrofti infection.