Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection
Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection
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DOI：
10.1126/science.1099250
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发表时间：
2004-08-13
期刊：
影响因子：
56.9
通讯作者：
Nakayama, J
中科院分区：
文献类型：
--
作者：
Kawakubo, M;Ito, Y;Nakayama, J
幽门螺杆菌感染了近一半的人的胃，但大多数被感染的人仍然没有症状，这表明宿主对这种细菌有防御。由于幽门螺杆菌很少在胃粘膜的深层部分发现，在那里表达具有末端α 1,4-连接n -乙酰氨基葡萄糖的o -聚糖，我们测试了这些o -聚糖是否可能影响幽门螺杆菌的生长。在这里，我们报道了这些o -聚糖对幽门螺杆菌具有抗菌活性，抑制其生物合成胆固醇- α - d -葡萄糖吡喃苷，这是细胞壁的主要成分。因此，胃粘蛋白中独特的o -聚糖似乎是一种天然抗生素，保护宿主免受幽门螺杆菌感染。
Helicobacter pylori infects the stomachs of nearly a half the human population, yet most infected individuals remain asymptomatic, which suggests that there is a host defense against this bacterium. Because H. pylori is rarely found in deeper portions of the gastric mucosa, where O-glycans are expressed that have terminal alpha1,4-linked N-acetylglucosamine, we tested whether these O-glycans might affect H. pylori growth. Here, we report that these O-glycans have antimicrobial activity against H. pylori, inhibiting its biosynthesis of cholesteryl-alpha-D-glucopyranoside, a major cell wall component. Thus, the unique O-glycans in gastric mucin appeared to function as a natural antibiotic, protecting the host from H. pylori infection.