Prevalence of Simple Renal Cysts in Acromegaly
Prevalence of Simple Renal Cysts in Acromegaly
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DOI：
10.2169/internalmedicine.55.6560
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发表时间：
2016-01-01
影响因子：
1.2
通讯作者：
Takahashi, Yutaka
中科院分区：
文献类型：
--
作者：
Yamamoto, Masaaki;Matsumoto, Ryusaku;Takahashi, Yutaka
目的肢端肥大症的合并症可累及多种器官。然而，肾脏结构性合并症，如囊肿的参与，迄今为止仍然在很大程度上未知。在这项单中心研究中，我们旨在确定日本肢端肥大症患者中单纯性肾囊肿的患病率和相关因素。方法分析了1986年至2012年在科比大学医院诊断的71例肢端肥大症患者，所有患者均接受腹部超声检查。结果在这71例患者中，23例（32.4%）表现为单纯性肾囊肿。与没有肾囊肿的患者相比，患有肾囊肿的肢端肥大症患者的年龄往往显着增加，吸烟率更高，并且在口服葡萄糖耐量试验（OGTT）期间生长激素（GH）的最低水平更高。多因素Logistic回归分析显示年龄、吸烟和GH最低值是肾囊肿的独立相关因素。有趣的是，肾囊肿的数量与OGTT期间的基础GH水平和最低GH水平呈正相关（r=0.66，p
Objective Various organs are known to be affected by the comorbidities of acromegaly. However, the involvement of renal structural comorbidities, such as cysts, has so far remained largely unknown. In this single-center study, we aimed to determine the prevalence and factors associated with simple renal cysts in Japanese patients with acromegaly.Methods A total of 71 consecutive patients with acromegaly were analyzed, who all underwent abdominal ultrasonography at diagnosis between 1986 and 2012 at Kobe University Hospital.Results Of these 71 patients, 23 (32.4%) exhibited simple renal cysts. Acromegalic patients with renal cysts tended to be significantly older, had a higher prevalence of smoking- and higher nadir growth hormone (GH) levels during the oral glucose tolerance test (OGTT) than did those without renal cysts. A multivariate logistic regression analysis showed age, smoking, and nadir GH to be independent factors associated with renal cysts. Interestingly, the number of renal cysts positively correlated with both the basal GH levels and nadir GH levels during OGTT (r=0.66, p