The role of skin ulceration in breast carcinoma staging and outcome
The role of skin ulceration in breast carcinoma staging and outcome
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DOI：
10.1111/tbj.12830
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发表时间：
2018-01-01
期刊：
影响因子：
2.1
通讯作者：
Jacobson, Rebecca
中科院分区：
文献类型：
--
作者：
Khoury, Thaer;Gaudioso, Carmelo;Jacobson, Rebecca
乳腺癌伴皮肤溃疡被认为是一种局部晚期疾病。本研究的目的是调查SU是否是一个独立的不利因素。研究纳入了SU乳腺癌患者（n=111）。一个子集（n=38，研究队列）与无SU的病例（n=38，匹配队列）匹配;比较这些组之间的生存分析。然后，将病例（n=80）独立于SU分期为I、II或III期。分析无病生存期（DFS）和总生存期（OS）。肿瘤较大的患者比肿瘤较小的患者更容易出现远处转移（P=.004）。在匹配病例中，研究队列的5年DFS概率为53%，匹配队列为58%;研究队列的OS为75%，匹配队列为84%，无统计学显著差异。然而，肿瘤有SU的患者有DFS恶化的趋势。当根据肿瘤大小和淋巴结状态（I、II或III）对病例进行分期时，OS具有统计学意义（P= 0.047），但DFS无统计学意义（P= 0.195）。相对较小的肿瘤与SU的疾病程度相似，在早期疾病的患者中观察到。生存分析表明，SU可能不是一个不利因素。然而，需要更多的病例来进一步研究这一发现。
Breast carcinoma with skin ulceration (SU) is considered a locally advanced disease. The purpose of the study is to investigate if SU is an independent adverse factor. Breast carcinoma patients with SU (n=111) were included in the study. A subset (n=38, study cohort) was matched with cases that had no SU (n=38, matched cohort); the survival analyses were compared between these groups. Then, cases (n=80) were staged independent from SU into stage I, II or III. Disease free survival (DFS) and overall survival (OS) were analyzed. Patients with larger tumors tended to present with distant metastases more often than patients with smaller tumors (P=.004). In the matched cases, the 5-year DFS probability was 53% for the study cohort and 58% for the matched cohort; and for OS 75% for the study cohort and 84% for the matched cohort with no statistical significant difference. However, there was a trend towards worse DFS for the patients whose tumors had SU. When the cases were staged based on tumor size and node status (I, II or III), the OS was statistically significant (P=.047) but not the DFS (P=.195). Relatively small tumors with SU had an extent of disease similar to that observed in patients with early stages disease. The survival analysis suggests that SU may not be an adverse factor. However, more cases are needed to further examine this finding.