Wolbachia infections that reduce immature insect survival: Predicted impacts on population replacement
Wolbachia infections that reduce immature insect survival: Predicted impacts on population replacement
复制标题
DOI：
10.1186/1471-2148-11-290
复制
发表时间：
2011-10-05
影响因子：
3.4
通讯作者：
Dobson, Stephen L.
中科院分区：
文献类型：
--
作者：
Crain, Philip R.;Mains, James W.;Dobson, Stephen L.
背景：沃尔巴克氏细菌的进化成功，其感染在无脊椎动物中广泛存在，很大程度上归功于一种能力，即在不施加大量适应成本的情况下操纵宿主繁殖。在这里，我们描述了一个具有确定性未成熟生活方式和随机成年女性生活方式的阶段结构模型。为了更好地理解沃尔巴克氏菌入侵未受感染的宿主群体，进行了模拟。该模型包含了传统的沃尔巴克氏菌参数(细胞质不亲和性水平、母体遗传、感染雌虫的相对繁殖力和沃尔巴克氏菌的初始感染频率)和一个新的参数--相对幼虫活力(RLV)，即感染幼虫相对于未感染幼虫的存活率。结果：RLV参数是沃尔巴克氏菌入侵和建立的最重要的决定因素。具体地说，在种群替换发生之前，受感染的未成熟宿主的适合度必须接近于未受感染的宿主的适合度。此外，RLV的微小下降抑制了沃尔巴克氏菌的入侵，尽管存在高水平的细胞质不相容、母体遗传和低成人健身成本。结论：本文描述的模型采用了一种新的方法来理解沃尔巴克氏菌通过具有明确动态的种群的传播。通过结合随机的成年女性生活方式和确定性的未成熟/成年男性生活方式，该模型预测，即使是那些导致幼年存活率略有下降的沃尔巴克氏菌感染，也不太可能在宿主群体中入侵和传播。这些结果与最近关于自然种群更替事件的理论和经验研究以及拟议的应用研究有关，这些研究将使用沃尔巴克氏菌作为操纵昆虫种群的工具。
Background: The evolutionary success of Wolbachia bacteria, infections of which are widespread in invertebrates, is largely attributed to an ability to manipulate host reproduction without imposing substantial fitness costs. Here, we describe a stage-structured model with deterministic immature lifestages and a stochastic adult female lifestage. Simulations were conducted to better understand Wolbachia invasions into uninfected host populations. The model includes conventional Wolbachia parameters (the level of cytoplasmic incompatibility, maternal inheritance, the relative fecundity of infected females, and the initial Wolbachia infection frequency) and a new parameter termed relative larval viability (RLV), which is the survival of infected larvae relative to uninfected larvae.Results: The results predict the RLV parameter to be the most important determinant for Wolbachia invasion and establishment. Specifically, the fitness of infected immature hosts must be close to equal to that of uninfected hosts before population replacement can occur. Furthermore, minute decreases in RLV inhibit the invasion of Wolbachia despite high levels of cytoplasmic incompatibility, maternal inheritance, and low adult fitness costs.Conclusions: The model described here takes a novel approach to understanding the spread of Wolbachia through a population with explicit dynamics. By combining a stochastic female adult lifestage and deterministic immature/adult male lifestages, the model predicts that even those Wolbachia infections that cause minor decreases in immature survival are unlikely to invade and spread within the host population. The results are discussed in relation to recent theoretical and empirical studies of natural population replacement events and proposed applied research, which would use Wolbachia as a tool to manipulate insect populations.