Genetic determination of adiponectin and its relationship with body fat topography in multigenerational families of Aftican heritage
Genetic determination of adiponectin and its relationship with body fat topography in multigenerational families of Aftican heritage
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DOI：
10.1016/j.metabol.2006.09.019
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发表时间：
2007-02-01
影响因子：
9.8
通讯作者：
Zmuda, Joseph M.
中科院分区：
文献类型：
--
作者：
Miljkovic-Gacic, Iva;Wang, Xiaojing;Zmuda, Joseph M.
脂联素是一种脂肪特异性蛋白，与肥胖、胰岛素敏感性和糖尿病呈负相关。很少有研究探讨遗传在非洲血统个体脂联素调节中的作用及其与体脂肪的关系。因此，我们通过放射免疫测定法测量了 402 名年龄在 18 至 103 岁之间的个体的空腹血清脂联素水平，这些个体属于相对同质的多巴哥岛屿人口中的 7 个非洲血统多代家庭，并通过双能 X 射线吸收测定法 (DEXA) 测量了身体成分。脂联素遗传率为 33.2% (P < .01)，年龄、性别和体重指数解释了脂联素变异的 23.4%。性别特异性遗传力在男性中显着（遗传力，34%；P < .05），但在女性中则不然。体重指数与身体脂肪和脂联素百分比之间的负相关性（与年龄和身高无关）在女性中（所有 P 值 < .001）比男性更强。然而，男性（r = -0.40，P < .001）和女性（r = -0.44，P < .001）的躯干脂肪百分比始终与脂联素密切相关，与年龄和身高无关。这项研究表明，遗传因素是非洲裔加勒比人循环脂联素个体间差异的重要根源。在旨在绘制该人群糖尿病和肥胖基因图谱的研究中，脂联素可能作为一种有前景的定量中间性状。 (c) 2007 Elsevier Inc. 保留所有权利。
Adiponectin, an adipose-specific protein, is negatively associated with adiposity, insulin sensitivity, and diabetes. Very few studies have examined the role of heredity in the regulation of adiponectin and its association with body fat among individuals of African heritage. Thus, we measured fasting serum adiponectin levels by radioimmunoassay and body composition by dual-energy x-ray absorptiometry (DEXA) in 402 individuals aged 18 to 103 years belonging to 7 multigenerational families of African heritage in the relatively homogeneous island population of Tobago. Heritability of adiponectin was 33.2% (P < .01), and age, sex, and body mass index explained 23.4% of the variance in adiponectin. Sex-specific heritability was significant in men (heritability, 34%; P < .05), but not in women. The inverse associations between body mass index and percentage of body fat and adiponectin, independent of age and height, were much stronger in women (all P values < .001) than in men. However, percentage of trunk fat was consistently strongly associated with adiponectin in both men (r = -0.40, P < .001) and women (r = -0.44, P < .001), independent of age and height. This study suggests that genetic factors are a significant source of interindividual differences in circulating adiponectin among Afro-Caribbeans. Adiponectin may serve as a promising quantitative intermediate trait in studies designed to map the genes underlying diabetes and obesity in this population. (c) 2007 Elsevier Inc. All rights reserved.