Mechanisms and therapeutic prospects of polyphenols as modulators of the aryl hydrocarbon receptor
Mechanisms and therapeutic prospects of polyphenols as modulators of the aryl hydrocarbon receptor
复制标题
多酚作为芳烃受体调节剂的机制和治疗前景
DOI：
10.1039/c6fo01810f
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发表时间：
2017
期刊：
影响因子：
6.1
通讯作者：
Kou Xiaohong
中科院分区：
文献类型：
--
作者：
Xue Zhaohui;Li Dan;Yu Wancong;Zhang Qian;Hou Xiaonan;He Yulong;Kou Xiaohong
芳基碳氢化合物受体（AhR）是一种多效性核因子，最初被认为是外源代谢的“大师”，但最近被证明是许多正常生理事件的重要调节因子。了解以多酚（人类饮食中外源性 AhR 调节剂的最大来源）为代表的 AhR 靶向化合物的作用机制对于开发基于多酚的营养保健策略或预防与多酚摄入相关的 AHR 介导的毒性至关重要。在这篇综述中，基于过去十年的研究，我们总结了多酚 AhR 调节剂的功能模式。此外，我们对多酚作为 AhR 拮抗剂、选择性 AhR 调节剂和双重 AhR/ER 调节剂的药理学/治疗用途进行了简要的机制概述，并强调了它们在预防/治疗人类常见疾病/紊乱中的潜力。此外，还为多酚 AhR 调节剂的进一步机制研究提供了有趣的主题。
The aryl hydrocarbon receptor (AhR) is a pleiotropic nuclear factor that was originally recognized as a “master” of xenobiotic metabolism but demonstrated recently to be a vital regulator of many normal physiological events. Understanding of the mechanism of action of AhR-targeted compounds, as represented by polyphenols (the greatest source of xenobiotic AhR modulators in the human diet) is of critical importance for the development of polyphenol-based nutraceutical strategies or the prevention of AHR-mediated toxicity associated with polyphenol intake. In this review, based on studies conducted over the past decade, we summarized the modes of function of polyphenolic AhR modulators. Furthermore, we made a brief mechanistic synopsis of the pharmacological/therapeutic use of polyphenols as AhR antagonists, selective AhR regulators and dual AhR/ER modulators, and underscored their potential in the prevention/treatment of common human diseases/disorders. Additionally, interesting subjects for further mechanistic investigations on polyphenolic AhR modulators have been provided.