Endometriosis from thelarche to midteens: pathogenesis and prognosis, prevention and pedagogy.
Endometriosis from thelarche to midteens: pathogenesis and prognosis, prevention and pedagogy.
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DOI：
10.1016/j.jpag.2003.09.008
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发表时间：
2003-12-01
影响因子：
1.8
通讯作者：
Mitwally, Mohamed F M
中科院分区：
文献类型：
--
作者：
Batt, Ronald E;Mitwally, Mohamed F M
北美儿科和青少年妇科亚专业的创始人约翰霍夫曼首先将子宫内膜异位症的诊断与乳房初长联系起来。随后，子宫内膜异位症被诊断为青春期早期之间的乳房初潮和月经初潮。基于确凿的证据，我们建议将胚胎苗勒管剩余理论加入到目前公认的子宫内膜异位症发病机制的理论中。这篇文章主张承认胚胎苗勒管残余是一些子宫内膜异位症病例的发病机制，而这些病例没有被公认的理论解释。沿着霍夫曼，我们建议将乳房初长作为一个发育基准，在此之后，子宫内膜异位症被纳入慢性盆腔疼痛的鉴别诊断。因此，为了重新关注青春期早期的研究和患者护理，本综述仅限于乳房初起至16岁生日的年轻女性发生的子宫内膜异位症。将子宫内膜异位症与乳房初长联系起来，对于青少年的发病机制、早期诊断、预后、治疗、教育和长期护理具有重要意义。
John Huffman, a founder of the subspecialty of pediatric and adolescent gynecology in North America, first related the diagnosis of endometriosis to thelarche. Subsequently, endometriosis was diagnosed in early puberty between thelarche and menarche. Based on solid evidence, we suggest that the theory of embryonic mullerian rests be added to currently accepted theories of pathogenesis of endometriosis. This article argues for recognition of embryonic mullerian rests as the pathogenesis of some cases of endometriosis not explained by accepted theories. Along with Huffman, we propose that thelarche be recognized as a developmental benchmark, after which endometriosis is included in the differential diagnosis of chronic pelvic pain. Thus, in an effort to refocus research and patient care to early adolescence, this review is limited to endometriosis occurring in young women from thelarche to their sixteenth birthday. Relating endometriosis to thelarche has fundamental implications for pathogenesis, early diagnosis, prognosis, treatment, education, and long-term care of adolescents.