Transient decreases in forelimb gait and ground reaction forces following rotator cuff injury and repair in a rat model
Transient decreases in forelimb gait and ground reaction forces following rotator cuff injury and repair in a rat model
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DOI：
10.1016/j.jbiomech.2009.10.031
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发表时间：
2010-03-03
影响因子：
2.4
通讯作者：
Soslowsky, Louis J.
中科院分区：
文献类型：
--
作者：
Sarver, Joseph J.;Dishowitz, Michael I.;Soslowsky, Louis J.
由于愈合不充分，手术修复撕裂的肩袖肌腱往往失败，限制了上肢功能的恢复。大鼠经常用于研究肩袖愈合;然而，很少有系统能够量化前肢功能，以解释组织水平愈合的临床意义。我们构建了一个设备来捕获图像，地面反作用力和扭矩，动物在狭窄的走道上走动，并用它来评估前肢功能未受伤的控制和手术受伤/修复的动物。记录术前（D-1）和术后3、7、14、28和56天的动态数据。通过分析腹部图像确定速度以及步宽和步长，并将地面反作用力标准化为体重。速度平均为22 +/- 6 cm/s，不受修复或时间的影响。步宽和未受伤的动物的长度相比，以及与我们以前的系统测量的值。前肢主要用于制动（-1.6 +/- 1.5% vs +2.5 +/- 0.6%），重量低于后肢（49 +/- 5% vs 58 +/- 4%），未受伤对照动物的两侧无差异（49 +/- 5% vs 46 +/- 5%）。修复动物的步长和地面反作用力在开始时（术后第3、7和14天）显著小于对照组，但到第28天时则不是。我们的新器械提供了与我们以前的系统和现有文献一致的未受伤的动态数据，并测量了与我们的手术模型预期的缺陷一致的前肢功能减少。(C)2009爱思唯尔有限公司保留所有权利。
Due to inadequate healing, surgical repairs of torn rotator cuff tendons often fail, limiting the recovery of upper extremity function. The rat is frequently used to study rotator cuff healing; however, there are few systems capable of quantifying forelimb function necessary to interpret the clinical significance of tissue level healing. We constructed a device to capture images, ground reaction forces and torques, as animals ambulated in a confined walkway, and used it to evaluate forelimb function in uninjured control and surgically injured/repaired animals. Ambulatory data were recorded before (D-1), and 3, 7, 14, 28 and 56 days after surgery. Speed as well as step width and length were determined by analyzing ventral images, and ground reaction forces were normalized to body weight. Speed averaged 22 +/- 6 cm/s and was not affected by repair or time. Step width and length of uninjured animals compared well to values measured with our previous system. Forelimbs were used primarily for braking (-1.6 +/- 1.5% vs +2.5 +/- 0.6%), bore less weight than hind limbs (49 +/- 5% vs 58 +/- 4%), and showed no differences between sides (49 +/- 5% vs 46 +/- 5%) for uninjured control animals. Step length and ground reaction forces of the repaired animals were significantly less than control initially (days 3,7 and 14 post-surgery), but not by day 28. Our new device provided uninjured ambulatory data consistent with our previous system and available literature, and measured reductions in forelimb function consistent with the deficit expected by our surgical model. (C) 2009 Elsevier Ltd. All rights reserved.