Strain and Exercise-Induced Pulmonary Hypertension.
Strain and Exercise-Induced Pulmonary Hypertension.
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劳损和运动引起的肺动脉高压。
DOI：
10.1016/j.amjcard.2023.08.008
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Pandey,AmitabhC
中科院分区：
文献类型：
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作者：
Shen,ChristineP;Bagsic,SamanthaRSpierling;Pandey,AmitabhC
方法这是一项对2017年至2020年接受运动RHC的患者进行的单中心回顾性分析。排除RHC前1年至RHC后1个月无超声心动图、血流动力学数据缺失、TTE不适合应变或机械循环支持的患者。根据欧洲心血管成像协会/美国超声心动图协会/行业工作组，在TTE上进行左、右心房和心室应变。比较mPAP/CO斜率3. 0和3. 0之间的TTE和血流动力学< versus>。使用Student t检验将参数描述为平均值±SD。使用错误发现率校正来调整p值。P< 0.05有统计学意义。使用R v.4.0进行分析。3（R基金会统计计算，维也纳，奥地利）。结果总共有38 51例患者进行运动RHC符合纳入标准，并进行应变评估。7例患者被排除植入左心室辅助装置。6例患者因缺失饱和度而被排除。17名患者的mPAP/CO斜率> 3（平均5.1），与EIPH一致。21例患者的mPAP/CO斜率< 3（平均2.1）。房颤在mPAP/CO< 3的患者中更常见（11/21 vs 3/17，p= 0.04）。
MethodsThis was a single-center, retrospective review of patients who underwent exercise RHC 2017 to 2020. Patients were excluded for no echocardiogram from 1 year before to 1 month after RHC, missing hemodynamic data, TTE unsuitable for strain, or mechanical circulatory support. Left and right atrial and ventricular strain were performed on TTE based on European Association of Cardiovascular Imaging/American Society of Echocardiography/Industry Task Force. TTE and hemodynamics were compared between mPAP/CO slope< versus> 3. Parameters were described as mean±SD using Student's t test. p Values were adjusted using false discovery rate correction. p< 0.05 were statistically significant. Analyses were conducted using R v. 4.0. 3 (The R Foundation for Statistical Computing, Vienna, Austria).ResultsIn total, 38 of 51 patients who underwent exercise RHC met inclusion criteria and underwent strain assessment. Seven patients were excluded from implanted left ventricular assist device. Six patients were excluded for missing saturation. Seventeen patients had mPAP/CO slope> 3 (mean 5.1), consistent with EIPH. Twenty-one patients had mPAP/CO slope< 3 (mean 2.1). Atrial fibrillation was more common in patients mPAP/CO< 3 (11 of 21 vs 3 of 17, p= 0.04).