Beyond mitochondria: Alternative energy-producing pathways from all strata of life.
Beyond mitochondria: Alternative energy-producing pathways from all strata of life.
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DOI：
10.1016/j.metabol.2021.154733
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Jeschke MG
中科院分区：
文献类型：
--
作者：
Auger C;Vinaik R;Appanna VD;Jeschke MG
众所周知，线粒体是细胞的动力发电站，产生三磷酸腺苷（ATP），这是一种通用的能量货币。然而，电子传递链（ETC）最显著的优势，它的复杂性和效率，也是它最大的缺点。依赖于金属配合物（Fe-S簇、血红素）、脂质运动（如心磷脂）和辅助因子（包括α -硫辛酸和醌），氧化磷酸化容易受到环境毒素、细胞内活性氧（ROS）和饮食波动的影响。为此，值得注意的是，在大多数生物体中，ETC活动的时间中断很少是致命的，而且在需要时，通常会出现冗余的故障，以允许ATP继续产生。在这里，我们强调了从寄生内阿米巴原虫到细菌（如假单胞菌）以及复杂的真核系统中发现的代谢重组，这些代谢重组使这些物种能够适应并偶尔在恶劣环境中茁壮成长。这篇综述的总体目标是证明代谢网络的可塑性，并认识到在胁迫时期，生命会找到一条出路。
It is well-established that mitochondria are the powerhouses of the cell, producing adenosine triphosphate (ATP), the universal energy currency. However, the most significant strengths of the electron transport chain (ETC), its intricacy and efficiency, are also its greatest downfalls. A reliance on metal complexes (Fe-S clusters, hemes), lipid moities such as cardiolipin, and cofactors including alpha-lipoic acid and quinones render oxidative phosphorylation vulnerable to environmental toxins, intracellular reactive oxygen species (ROS) and fluctuations in diet. To that effect, it is of interest to note that temporal disruptions in ETC activity in most organisms are rarely fatal, and often a redundant number of failsafes are in place to permit continued ATP production when needed. Here, we highlight the metabolic reconfigurations discovered in organisms ranging from parasitic Entamoeba to bacteria such as pseudomonads and then complex eukaryotic systems that allow these species to adapt to and occasionally thrive in harsh environments. The overarching aim of this review is to demonstrate the plasticity of metabolic networks and recognize that in times of duress, life finds a way.
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DOI：
10.1016/j.bbagen.2014.09.028
发表时间：
2015-01-01
影响因子：
3
作者：
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影响因子：
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影响因子：
3.2
作者：
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DOI：
10.1161/hypertensionaha.109.135459
发表时间：
2009-12
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
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作者：
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