Lung allocation score: the Eurotransplant model versus the revised US model - a cross-sectional study
Lung allocation score: the Eurotransplant model versus the revised US model - a cross-sectional study
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DOI：
10.1111/tri.13262
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发表时间：
2018-08-01
影响因子：
3.1
通讯作者：
Gottlieb, Jens
中科院分区：
文献类型：
--
作者：
Smits, Jacqueline M.;Nossent, George;Gottlieb, Jens
欧洲移植（ET）和美国都使用肺分配评分（LAS）来分配供体肺。2015年，美国实施了一种新的计算分数的算法，而ET则使用商业规则对原始模型进行了微调。在当代患者队列中对两种模型进行了比较。计算ET活跃等候名单上的所有患者的排名位置和两种评分之间的相关性。2017年2月6日，581名患者活跃在肺移植等候名单上。ET和US的LAS中位数分别为32.56和32.70。两者的总体相关系数为0.71。43%的患者的LAS变化小于2点。美国的LAS比41%的患者低2个百分点以上，比16%的患者高2个百分点以上。所有诊断组的中位数和第90百分位数在两个分数之间没有差异。实施2015年美国LAS模式不会显著改变目前ET的等待名单。
Both Eurotransplant (ET) and the US use the lung allocation score (LAS) to allocate donor lungs. In 2015, the US implemented a new algorithm for calculating the score while ET has fine-tuned the original model using business rules. A comparison of both models in a contemporary patient cohort was performed. The rank positions and the correlation between both scores were calculated for all patients on the active waiting list in ET. On February 6th 2017, 581 patients were actively listed on the lung transplant waiting list. The median LAS values were 32.56 and 32.70 in ET and the US, respectively. The overall correlation coefficient between both scores was 0.71. Forty-three per cent of the patients had a < 2 point change in their LAS. US LAS was more than two points lower for 41% and more than two points higher for 16% of the patients. Median ranks and the 90th percentiles for all diagnosis groups did not differ between both scores. Implementing the 2015 US LAS model would not significantly alter the current waiting list in ET.