Insulin and proinsulin content of pancreases from diabetic and nondiabetic subjects.
Insulin and proinsulin content of pancreases from diabetic and nondiabetic subjects.
复制标题
糖尿病和非糖尿病受试者胰腺的胰岛素和胰岛素原含量。
作者：
Rastogi Gk;Sinha Mk;Dash Rj
用酸性乙醇从胰腺头、体和尾提取免疫反应性胰岛素（IRI）。研究对象为32例非糖尿病患者、11例成熟型糖尿病患者和4例青少年糖尿病患者。在非糖尿病患者中，IRI含量为每克湿胰腺0.1至4.8 u。尾巴的胰岛素含量最高，但胰腺的主体可以代表整个胰腺。11例成熟型糖尿病患者胰腺胰岛素含量为每克0.1 ~ 6.5 u。随着糖尿病病程的延长，该指标逐渐下降。4例青少年糖尿病患者胰腺IRI含量较低。通过胰腺提取物中的凝胶过滤估计，胰岛素样原成分的比例在胰岛素峰值的0.2%至5%之间，在糖尿病患者中没有差异。
The content of immunoreactive insulin (IRI) extractable with acid ethanol from the head, body and tail of the pancreas was. studied in thirty-two nondiabetics, eleven maturity-onset diabetics and four juvenile diabetics. In nondiabetics IRI content ranged from 0.1 to 4.8 U. per gram wet pancreas. The tail had the highest insulin content, but the body of the pancreas could be taken to represent the entire pancreas. The insulin content of pancreases from eleven maturity-onset diabetics ranged from 0.1 to 6.5 U. per gram wet pancreas. It showed a progressive decline with the duration of diabetes. The IRI content of pancreases from four juvenile diabetics was low. The proportion of proinsulinlike component, estimated by gel filtration in the pancreatic extracts, ranged from 0.2 to 5 per cent of the insulin peak and was not different in diabetics.