Pseudomonas aeruginosa ExoT is a Rho GTPase-activating protein
Pseudomonas aeruginosa ExoT is a Rho GTPase-activating protein
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DOI：
10.1128/iai.68.10.6066-6068.2000
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发表时间：
2000-10-01
影响因子：
3.1
通讯作者：
Barbieri, JT
中科院分区：
文献类型：
--
作者：
Krall, R;Schmidt, G;Barbieri, JT
在CHO细胞中瞬时表达ExoT可刺激细胞圆化和肌动蛋白重组，生化研究表明ExoT是RhoA、rac1和CDc42的GTP酶激活蛋白。综上所述，这些数据表明ExoT干扰Rho信号转导通路，Rho信号转导通路调节肌动蛋白的组织、胞吐作用、细胞周期进展和吞噬作用。
Transient intracellular expression of ExoT in CHO cells stimulated cell rounding and actin reorganization, Biochemical studies showed that ExoT was a GTPase-activating protein for RhoA, Rac1, and Cdc42. Together, these data show that ExoT interferes with Rho signal transduction pathways, which regulate actin organization, exocytosis, cell cycle progression, and phagocytosis.