Clinical advantages of carbon-ion radiotherapy
Clinical advantages of carbon-ion radiotherapy
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DOI：
10.1088/1367-2630/10/7/075009
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发表时间：
2008-07-28
影响因子：
3.3
通讯作者：
Mizoe, Junetsu
中科院分区：
文献类型：
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作者：
Tsujii, Hirohiko;Kamada, Tadashi;Mizoe, Junetsu
碳离子放射治疗（C-ion RT）具有物理和生物学优势。它于1994年在NIRS开始使用千叶的重离子医用加速器（HIMAC）;从那时起，已经对近4000名患有各种肿瘤的患者进行了50多项方案研究。临床经验表明，C离子放射治疗在头颈部、颅底、肺、肝、前列腺、骨和软组织、直肠癌的盆腔复发等区域，以及对于包括腺癌、腺样囊性癌、恶性黑色素瘤和各种类型的肉瘤在内的组织学类型有效，而光子治疗对这些区域的效果可能较差。此外，与光子和质子RT相比，在不增加毒性的情况下显着减少了总体治疗时间和分数。目前，每个患者的照射次数平均为13次，分布在大约三周内。这意味着在碳疗法设施中，在相同的时间段内可以治疗比其他模式可能治疗的更多的患者。
Carbon-ion radiotherapy (C-ion RT) possesses physical and biological advantages. It was started at NIRS in 1994 using the Heavy Ion Medical Accelerator in Chiba (HIMAC); since then more than 50 protocol studies have been conducted on almost 4000 patients with a variety of tumors. Clinical experiences have demonstrated that C-ion RT is effective in such regions as the head and neck, skull base, lung, liver, prostate, bone and soft tissues, and pelvic recurrence of rectal cancer, as well as for histological types including adenocarcinoma, adenoid cystic carcinoma, malignant melanoma and various types of sarcomas, against which photon therapy could be less effective. Furthermore, when compared with photon and proton RT, a significant reduction of overall treatment time and fractions has been accomplished without enhancing toxicities. Currently, the number of irradiation sessions per patient averages 13 fractions spread over approximately three weeks. This means that in a carbon therapy facility a larger number of patients than is possible with other modalities can be treated over the same period of time.