Streptomycin, a substance exhibiting antibiotic activity against gram positive and gram-negative bacteria
Streptomycin, a substance exhibiting antibiotic activity against gram positive and gram-negative bacteria
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DOI：
10.3181/00379727-55-14461
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发表时间：
1944-01-01
影响因子：
--
通讯作者：
Waksman, SA
中科院分区：
文献类型：
--
作者：
Schatz, A;Bugie, E;Waksman, SA
链霉素是从两株与灰色放线菌有亲缘关系的放线菌中分离得到的一种新的抗菌物质。它在水溶性、分离方式、对革兰氏阴性菌的选择性活性和对动物的有限毒性方面与链丝菌素相似。这两种物质在其各自的抑菌谱的性质以及对不同细菌的定量作用方面不同。这似乎是在处理两种密切相关的化合物。
Streptomycin, a new antibacterial substance, was isolated from 2 strains of an actinomyces related to Actinomyces griseus. It resembles streptothricin in its solubility in water, mode of isolation, selective activity against gram-negative bacteria, and limited toxicity to animals. The 2 substances differ in the nature of their respective bacteriostatic spectra as well as in their quantitative action upon different bacteria. It appears that one is dealing here with 2 closely related chemical compounds.