An experimental model of Stanford type B aortic dissection with intravenous epinephrine injection
An experimental model of Stanford type B aortic dissection with intravenous epinephrine injection
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静脉注射肾上腺素Stanford B型主动脉夹层实验模型
DOI：
10.1016/j.kjms.2012.08.033
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发表时间：
2013-04-01
影响因子：
3.3
通讯作者：
Fu, Wei-Guo
中科院分区：
文献类型：
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作者：
Wang, Li-Xin;Wang, Yu-Qi;Fu, Wei-Guo
本研究的目的是建立一种具有长期假腔的主动脉夹层(AD)的实验模型，以开发新的治疗Stanford B型主动脉夹层的方法。成年比格犬16只，体重14~18 kg。暴露和部分夹闭后，降主动脉穿过外膜至中膜深度的1/3。腹主动脉壁按破裂分为两层。然后横切内层周长的一半。近端各层与远端外层全部吻合。立即使用肾上腺素扩张假腔，必要时使用硝酸甘油终止作用。术后即刻、术后1周、1个月行数字减影血管造影(DSA)和CT血管造影(CTA)检查。分别于术后1天、3个月、1年、2年进行随访。12只狗的手术都很成功。注射肾上腺素后立即观察到夹层形成，并经DSA和CTA证实。我们的结果显示了AD的典型特征，如撕裂、隔膜和真假腔。这是一种简单可行的静脉注射肾上腺素建立Stanford B型AD模型的方法。在这个AD犬模型中，假腔具有良好的长期通畅性，解剖平面与人类AD的解剖平面相似。该模型可能有助于开发治疗斯坦福大学B型AD的新方法。版权所有(C)2012，高雄医科大学。爱思唯尔台湾有限责任公司出版。版权所有。
The aim of this study was to create an experimental model of aortic dissection (AD) with a long-term patent false lumen to develop new treatments for Stanford type B aortic dissection. Sixteen adult beagle dogs (weight 14-18 kg) were used. After exposure and partially clamping, the descending aorta was cut through the adventitia to one-third of the depth of the tunica media. The aortic wall was divided into two layers by raspatory. Then half the circumference of the inner layer was cut transversely. All of the proximal layers and the distal outer layers were anastomosed together. Epinephrine was immediately used to expand the false lumen, and the effect was terminated using nitroglycerin when necessary. All dogs underwent both digital subtraction angiography (DSA) and computed tomography angiography (CTA) immediately after and 1 week and 1 month after surgery. The dogs were followed up at 1 day, 3 months, 1 year, and 2 years. The surgery was successful in 12 dogs. Dissection formation was observed immediately after epinephrine administration and confirmed by DSA and CTA. Our results showed typical characteristics of AD, such as a tear, septum, and true and false lumens. This is an easy and feasible way of developing a Stanford type B AD model by intravenous injection of epinephrine. In this canine model of AD, the false lumen has excellent long-term patency and the dissection plane is histologically similar to that in human AD. This model may contribute to the development of new treatments for Stanford type B AD. Copyright (C) 2012, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.