Evaluation of the effect of training using auditory stimulation on rhythmic movement in Parkinsonian patients -: a combined motor and [18F]-FDG PET study
Evaluation of the effect of training using auditory stimulation on rhythmic movement in Parkinsonian patients -: a combined motor and [18F]-FDG PET study
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DOI：
10.1016/j.parkreldis.2005.11.002
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发表时间：
2006-01-01
影响因子：
4.1
通讯作者：
Cudeiro, J
中科院分区：
文献类型：
--
作者：
Del Olmo, M;Arias, P;Cudeiro, J
简介：先前已证明使用听觉提示的康复计划可以减少帕金森病患者步态的运动变异性。 目的和方法：我们研究了 9 名帕金森病 (PD) 患者在进行身体康复计划之前和之后的手指敲击和步态的时间变异性。对这些受试者进行使用 2-脱氧-2[F-18]氟-D-葡萄糖 (FDG) 的正电子发射断层扫描 (PET)，以寻找完成康复计划后大脑代谢活动的变化。结果：变异性的减少不仅体现在步态中，还体现在其他重复运动（例如手指敲击）中。此外，这里我们显示了这些患者与健康对照相比静息区域大脑葡萄糖利用率的差异（PD组右顶叶和颞叶、左颞叶和额叶代谢显着低下-p<0.001，左侧小脑代谢亢进）以及重复运动能力改善后的具体变化（显着代谢增量-p<0.001-右侧PD组）结论：虽然我们的研究不能让我们得出明确的结论，但它提供了关于 PD 听觉刺激的神经基础的新信息。我们的结果扩展了之前的研究结果，表明帕金森病患者参与身体康复计划后，两种节律运动的时间变异性得到改善，同时参与感觉运动处理的几个大脑区域的葡萄糖摄取也发生了变化。 (c) 2006 Elsevier Ltd. 保留所有权利。
Introduction: A programme of rehabilitation using auditory cues has previously been shown to decrease movement variability in the gait of Parkinsonian patients.Objective and methods: We studied the temporal variability of finger-tapping and gait in 9 patients with Parkinson's disease (PD) before and after they undertook a physical rehabilitation programme. Positron Emission Tomography (PET) using 2-deoxy-2[F-18]fluoro-D-glucose (FDG) was performed in these subjects to look for changes in metabolic brain activity after completion of the rehabilitation program.Results: The reduction of variability was seen not only in gait but also other repetitive movements such as finger tapping. Furthermore, here we show differences in resting regional cerebral glucose utilisation in these patients compared to healthy controls (significant hypometabolism-p < 0.001-for the PD group in the right parietal and temporal lobes, left temporal and frontal lobes and a hypermetabolism in the left cerebellum) and specific changes following the improvements in repetitive movement abilities (significant metabolic increment-p < 0.001-in the PD group in the right cerebellum and in the right parietal and temporal lobes).Conclusions: Although our study does not allow us to draw firm conclusions, it provides new information on the neural basis of auditory stimulation in PD. Our results extend those from previous studies to show improvement in the temporal variability of two types of rhythmic movements after participation by PD patients in a physical rehabilitation programme, along with changes in glucose uptake in several brain areas involved in sensorimotor processing. (c) 2006 Elsevier Ltd. All rights reserved.