Three interrelated themes in current breast cancer research: gene addiction, phenotypic plasticity, and cancer stem cells.
Three interrelated themes in current breast cancer research: gene addiction, phenotypic plasticity, and cancer stem cells.
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DOI：
10.1186/bcr2887
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发表时间：
2011-10-25
期刊：
影响因子：
--
通讯作者：
Bolon B
中科院分区：
文献类型：
--
作者：
Cardiff RD;Couto S;Bolon B
最近对乳腺癌生物学的研究涉及三个相互关联的主题，这些主题建立在临床和实验观察的结合上。核心概念是基因成瘾。临床困境是逃避基因成瘾，这在一定程度上是由表型可塑性介导的，例如上皮到间质转化和间质到上皮的转化。最后，随着时间的推移，癌症干细胞现在被认为是最小残留疾病和恶性进展的基础。这些主题在乳腺癌中相互合作，因为诱导上皮细胞向间充质细胞的转化增强了癌症干细胞的自我更新和表达，这被认为有助于肿瘤抵抗。
Recent efforts to understand breast cancer biology involve three interrelated themes that are founded on a combination of clinical and experimental observations. The central concept is gene addiction. The clinical dilemma is the escape from gene addiction, which is mediated, in part, by phenotypic plasticity as exemplified by epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition. Finally, cancer stem cells are now recognized as the basis for minimal residual disease and malignant progression over time. These themes cooperate in breast cancer, as induction of epithelial-to-mesenchymal transition enhances self-renewal and expression of cancer stem cells, which are believed to facilitate tumor resistance.
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DOI：
10.1186/bcr920
发表时间：
2004
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Dontu G;Jackson KW;McNicholas E;Kawamura MJ;Abdallah WM;Wicha MS
通讯作者：
Wicha MS
影响因子：
0.7
作者：
Angela Nieto, M.
通讯作者：
Angela Nieto, M.
影响因子：
2.5
作者：
Creighton, Chad J.;Chang, Jenny C.;Rosen, Jeffrey M.
通讯作者：
Rosen, Jeffrey M.
影响因子：
5.2
作者：
D'Assoro AB;Leontovich A;Amato A;Ayers-Ringler JR;Quatraro C;Hafner K;Jenkins RB;Libra M;Ingle J;Stivala F;Galanis E;Salisbury JL
通讯作者：
Salisbury JL
影响因子：
7.4
作者：
Damonte, Patrizia;Hodgson, J. Graeme;Borowsky, Alexander D.
通讯作者：
Borowsky, Alexander D.