Age-related changes in nephrosclerosis in a multiethnic living kidney donor cohort.
Age-related changes in nephrosclerosis in a multiethnic living kidney donor cohort.
复制标题
多民族活体肾捐献者队列中肾硬化的年龄相关变化。
DOI：
10.1016/j.kint.2023.04.028
复制
发表时间：
2023
影响因子：
19.6
通讯作者：
Husain,SAli
中科院分区：
文献类型：
--
作者：
Emmons,BrendanR;Batal,Ibrahim;Radhakrishnan,Jai;Husain,SAli
结果我们确定了我们中心(2010年1月至2022年7月)1053名活体捐赠者进行了植入活组织检查(见补充方法)。年龄中位数为44岁，其中621人(59%)为白人种族/族裔，125人(12%)为黑人，209人(20%)为西班牙裔，78人(7%)为亚洲人(补充表S1)。56名捐献者(5%)有高血压病史，其中47人有24小时动态血压结果，显示读数的中位数百分比讨论综合起来，这些观察证实了EGFR随年龄的下降发生在一组高度筛查的健康个体中，且不会因肾硬化症而改变，1，2，3，使我们能够为成人生命周期中正常的GS提供参考范围，这些捐赠者来自广泛筛查肾功能障碍迹象的捐赠者。他们还证明，正常的GS值不会因种族而异。
ResultsWe identified 1053 living donors at our center (January 2010–July 2022) who had implantation biopsies performed (see Supplementary Methods). Median age was 44 years, 621 (59%) identified as White race/ethnicity, 125 (12%) identified as Black, 209 (20%) identified as Hispanic, and 78 (7%) identified as Asian (Supplementary Table S1). Fifty-six (5%) donors had history of hypertension, among whom 47 had 24-hour ambulatory blood pressure results available, showing median percentage of readingsDiscussionTaken together, these observations corroborate an age-dependent decrease in eGFR that occurs in a cohort of highly screened, healthy individuals and that is not modified by nephrosclerosis, 1, 2, 3 and allow us to provide reference ranges for normal GS across the adult lifespan derived from donors extensively screened for signs of kidney dysfunction. They also demonstrate that normal GS values do not differ by race.