Neuropsychological functioning in youth with bipolar disorder
Neuropsychological functioning in youth with bipolar disorder
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DOI：
10.1016/j.biopsych.2005.07.019
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发表时间：
2005-10-01
影响因子：
10.6
通讯作者：
Biederman, J
中科院分区：
文献类型：
--
作者：
Doyle, AE;Wilens, TE;Biederman, J
背景：关于双相情感障碍(BPD)青少年的神经心理状态，以及这一人群的认知缺陷是否与注意缺陷/多动障碍(ADHD)共病有关，目前还知之甚少。方法：采用韦氏儿童与成人智力量表(第三版)、Stroop测验、威斯康星卡片分类测验、Ret-Osterreith复杂图形测验、听觉工作记忆连续操作测验、言语学习测验和大范围成就测验(第三版)对57例BPD青年和46例健康对照受试者进行神经心理测试。此外，在干扰控制、抽象问题解决和语言学习方面，中等效应大小的减少是合理的，但不符合统计学意义的标准。结论：在控制ADHD后，患有BPD的青少年表现出与成人BPD相似的神经心理障碍。需要进一步的研究来了解这些损害的临床意义以及它们在儿童BPD潜在风险中的作用。
Background: Little is known about the neuropychological status of youth with, bipolar disorder (BPD) or whether cognitive deficits in this population are accounted for by comorbidity with attention deficit/hyperactivity disorder (ADHD). We compared neuropsychological and academic functioning of youth with and without DSM-IV BPD, controlling for effects of comorbid ADHD.Methods: Fifty-seven youth with BPD and 46 healthy control subjects were assessed on a battery of clinical neuropsychological measures including subtests from the Wechsler Intelligence Scales for Children and Adults (Third Editions), the Stroop, the Wisconsin Card Sorting Test, the Ret-Osterreith Complex Figure, an auditory working memory Continuous Performance Test, a measure of verbal learning, and the Wide Range Achievement Test-Third Edition.Results: Bipolar disorder was associated with impairments on subtests reflecting sustained attention, working memory, and processing speed after controlling for ADHD. Additionally, decrements of moderate effect sizes were ound,for measures of interference control, abstract problem solving, and verbal learning but did not meet criteria for statistical significance.Conclusions: After controlling for ADHD, youth with BPD show neuropsychological deficits similar to impairments found in adults with the disorder. Further studies are needed to understand the clinical implications of these impairments as well as their role in the underlying risk for pediatric BPD.