Do different endocytic pathways make different synaptic vesicles?
Do different endocytic pathways make different synaptic vesicles?
复制标题
不同的内吞途径会产生不同的突触小泡吗？
DOI：
10.1016/j.conb.2007.04.002
复制
发表时间：
2007
影响因子：
5.7
通讯作者：
Edwards,RobertH
中科院分区：
文献类型：
--
作者：
Voglmaier,SusanM;Edwards,RobertH
At a wide range of synapses, synaptic vesicles reside in distinct pools that respond to different stimuli. The recycling pool supplies the vesicles required for release in response to modest stimulation, whereas the reserve pool is mobilized only by strong stimulation. Multiple pathways have been proposed for the recycling of synaptic vesicles after exocytosis, but the relationship of these pathways to the different synaptic vesicle pools has remained unclear. Synaptic vesicle proteins have also been assumed to undergo recycling as a unit. However, emerging data indicate that differences in the association with distinct endocytic adaptors such as the heterotetrameric adaptor AP3 influence the trafficking of individual synaptic vesicle proteins, affecting the composition of synaptic vesicles and hence their functional characteristics. These observations might begin to account for differences in the properties of different vesicle pools.
