EVIDENCE OF SPOTTED-FEVER RICKETTSIAL INFECTION IN JAPAN AS DEMONSTRATED BY THE INDIRECT IMMUNOPEROXIDASE TEST
EVIDENCE OF SPOTTED-FEVER RICKETTSIAL INFECTION IN JAPAN AS DEMONSTRATED BY THE INDIRECT IMMUNOPEROXIDASE TEST
复制标题
DOI：
10.1111/j.1348-0421.1985.tb00914.x
复制
发表时间：
1985-01-01
影响因子：
2.6
通讯作者：
SUTO, T
中科院分区：
文献类型：
--
作者：
SUTO, T
与恙虫病（TD）相反，日本尚未记录斑点热群立克次体（SFGR）感染。Mahara等人(1)和Uchida(7)最近通过Weil-Felix （WF）反应和补体固定（CF）试验发现了几例SFGR感染病例。为了进一步调查上述病例，我们使用3种恙虫病立克次体（RT）原型菌株进行了间接免疫过氧化物酶（IP）试验(6)；两种SFG立克次体，即蜱传立克次体“泰国蜱斑疹伤寒，TT-118”（TTT）和“西伯利亚蜱斑疹伤寒，立克次体西伯利亚（STT）”，以及一种斑疹伤寒群立克次体“鼠斑疹伤寒”立克次体（MT）。第一位患者（表中病例2）于1984年5月在日本德岛县发现，第二位患者（病例3）于6月接受治疗。患者的症状与TD(1)相似，均为高热，四肢和躯干出现红斑病变并出血。第二例患者左臂有典型的“痂（黑肿）”。她在发病前约3天被蜱虫叮咬。1984年6月下旬，病人的血清从Mahara诊所送到我们这里，以确认TD。然而，在血清到达的当天，通过IP反应排除了TD(6)。一些其他立克次体感染被认为是由于血清在Weil-Felix （WF）反应中显示OX-2滴度增加（1,7）。7月下旬，在同一诊所发现了另一例症状相当严重的病例（第4号病例），该病例对强力霉素治疗也有反应。该病例的血清在对三种RT原型菌株的IP反应中抗体也呈阴性，但在WF中对Proteus OX-2抗体呈阳性（1,7）。1984年9月，在日本东京国立公共卫生研究所，在这三名患者的血清中检测到针对赤螺旋体和立克次体的CF抗体（1,7）。
In contrast to the Tsutsugamushi disease (TD), infection with spotted fever group rickettsiae (SFGR) has not been documented in Japan. Mahara et al (1) and Uchida (7) have recently identified several cases of infection with some kind of SFGR by the Weil-Felix (WF) reaction and complement fixation (CF) test. To further investigate the above cases, we performed the indirect immuno-peroxidase (IP) test (6) using three prototype strains of Rickettsia tsulsugamushi (RT); two strains of SFG rickettsia, ie, a strain of tick borne rickettsia" Thai tick typhus, TT-118"(TTT) and" Siberian tick typhus," Rickettsia sibirica (STT), and one typhus group rickettsia," murine typhus," Rickettsia typhi (MT). The first patient (Case No. 2 in the table) was seen in May, 1984 in Tokushima Pref. Japan, and the second one (Case No. 3) was treated in June. The symptoms of the patients were similar to those of TD (1) such as high fever and erythematous lesions on the extremities and trunk which became hemorrhagic. The second patient had a typical" eschar (tache noire)" on her left arm. She was bitten by ticks about 3 days before the onset of the disease. In late June, 1984, the sera of the patients were sent to us from the Mahara Clinic for confirmation of TD. However, TD was ruled out on the day the sera arrived by means of the IP reaction (6). Some other rickettsial infection was sus pectedbecause the sera showed an increase in OX-2 titers in the Weil-Felix (WF) reaction (1, 7). In late July, another case (Case No. 4) with rather severe symptoms was seen at the same clinic, which also responded to doxycycline therapy. The serum of this case was also negative for antibody in the IP reaction against three prototype strains of RT, but positive for Proteus OX-2 by WF (1, 7). In September, 1984, CF antibodies against R. akari and also R. rickettsii were detected at the National Institute of Public Health, Tokyo, Japan, in sera of these three patients (1, 7).