Dehydroepiandrosterone and ageing
Dehydroepiandrosterone and ageing
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DOI：
10.1016/j.beem.2004.02.006
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发表时间：
2004-09-01
影响因子：
7.4
通讯作者：
Arlt, W
中科院分区：
文献类型：
--
作者：
Arlt, W
脱氢表雄酮（DHEA）是由肾上腺网状层产生的主要类固醇，与皮质醇和醛固酮相反，其分泌随着年龄的增长而下降。这引起了人们对它作为“抗衰老”激素的假定作用的极大兴趣。然而，尚不清楚与年龄相关的DHEA分泌的生理性下降是否代表有害的缺乏。DHEA主要通过转化为性类固醇来发挥作用。此外，DHEA具有神经甾体性质，并可通过内皮细胞上的特异性结合位点表现出直接作用。有令人信服的证据表明DHEA对肾上腺皮质功能不全患者的有益作用，未来的研究将有望阐明其在接受药物糖皮质激素治疗的患者中的作用。然而，在健康的老年受试者中，目前来自随机对照试验的证据并不能证明DHEA的使用是合理的，没有报告主要的有益作用，此外，需要考虑对性类固醇依赖性肿瘤生长的潜在不良影响。
Dehydroepiandrosterone (DHEA) is the major steroid produced by the adrenal zona reticularis and, in contrast to cortisol and aldosterone, its secretion declines with ageing. This has generated major interest in its putative role as an 'anti-ageing' hormone. However, it is not clear that the age-associated, physiological decline in DHEA secretion represents a harmful deficiency. DHEA exhibits its action mainly by conversion to sex steroids. In addition, DHEA has neurosteroidal properties and may exhibit direct action via specific binding sites on endothelial cells. There is convincing evidence for beneficial effects of DHEA in patients with adrenal insufficiency and future research will hopefully elucidate its role in patients receiving pharmacological glucocorticoid treatment. However, in healthy elderly subjects, current evidence from randomised, controlled trials does not justify the use of DHEA, with no major beneficial effects reported and, in addition, potentially adverse effects on sex steroid-dependent tumour growth need to be considered.