The Effect of Pulse Sequence Parameters and Contrast Agent Dose on Percentage Signal Recovery in DSC-MRI: Implications for Clinical Applications
The Effect of Pulse Sequence Parameters and Contrast Agent Dose on Percentage Signal Recovery in DSC-MRI: Implications for Clinical Applications
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DOI：
10.3174/ajnr.a3477
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发表时间：
2013-07-01
影响因子：
3.5
通讯作者：
Schmainda, K. M.
中科院分区：
文献类型：
--
作者：
Boxerman, J. L.;Paulson, E. S.;Schmainda, K. M.
背景与目的：技术因素和病理生理因素均影响DSC-MR成像中的PSR。我们的目的是确定TE、翻转角度（）和对比剂剂量如何影响高级别胶质瘤的PSR。材料和方法：我们回顾性计算22例高级别胶质瘤患者的PSR图，比较3种DSC-MR成像方法：A (n = 7), = 35度，TE = 54 ms；B (n = 5), = 72度，TE = 30 ms；C (n = 10), = 90度，TE = 30 ms。方法A-C作为后续D方法动态成像的预负荷（C方法参数，双剂量造影剂）。我们比较了C和D方法的第一次和第二次注射的肿瘤PSR（配对t检验）和第一次注射获得方法分组的两次注射的肿瘤PSR（3组非参数单因素方差分析）。我们比较了第一次和第二次注射方法组肿瘤和正常脑的PSR（配对t检验）。结果：B、C两种方法首次注射后的PSR在肿瘤脑组织与正常脑组织中差异有统计学意义（P = 0.01）， A方法差异无统计学意义（P = 0.71）。首次注射肿瘤PSR随T1加权增加而增加，各方法分组的主效应显著（P = 0.0012），但首次注射正常脑（P = 0.93）、第二次注射肿瘤（P = 0.95）或正常脑（P = 0.13）无显著主效应。在C和D方法扫描的患者中，肿瘤患者第一次注射PSR显著高于第二次注射PSR （P = 0.037）和正常脑组织（P < 0.001）。结论：PSR在很大程度上取决于DSC-MR成像的T1加权，包括脉冲序列（TE）和造影剂（剂量、预负荷）参数，这对方案设计以及不同肿瘤类型和成像中心的PSR值的解释和比较具有重要意义。
BACKGROUND AND PURPOSE: Both technical and pathophysiologic factors affect PSR in DSC-MR imaging. We aimed to determine how TE, flip angle (), and contrast dose impact PSR in high-grade gliomas.MATERIALS AND METHODS: We retrospectively computed PSR maps for 22 patients with high-grade gliomas, comparing 3 DSC-MR imaging methods by using single-dose gadodiamide without preload administration: A (n = 7), = 35 degrees, TE = 54 ms; B (n = 5), = 72 degrees, TE = 30 ms; C (n = 10), = 90 degrees, TE = 30 ms. Methods A-C served as preload for subsequent dynamic imaging using method D (method C parameters but with double-dose contrast). We compared first- and second-injection tumor PSR for methods C and D (paired t test) and tumor PSR for both injections grouped by the first-injection acquisition method (3-group nonparametric 1-way ANOVA). We compared PSR in tumor and normal brain for each first- and second-injection method group (paired t test).RESULTS: First-injection PSR in tumor and normal brain differed significantly for methods B (P = .01) and C (P = .05), but not A (P = .71). First-injection tumor PSR increased with T1 weighting with a significant main effect of method groupings (P = .0012), but there was no significant main effect for first-injection normal brain (P = .93), or second-injection tumor (P = .95) or normal brain (P = .13). In patients scanned with methods C and D, first-injection PSR significantly exceeded second-injection PSR for tumor (P = .037) and normal brain (P < .001).CONCLUSIONS: PSR strongly depends on the T1 weighting of DSC-MR imaging, including pulse sequence (TE, ) and contrast agent (dose, preload) parameters, with implications for protocol design and the interpretation and comparison of PSR values across tumor types and imaging centers.