Seasonality associated with the serotonin 2A receptor - 1438 A/G polymorphism
Seasonality associated with the serotonin 2A receptor - 1438 A/G polymorphism
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DOI：
10.1016/j.jad.2006.05.001
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发表时间：
2006-10-01
影响因子：
6.6
通讯作者：
Kim, Leen
中科院分区：
文献类型：
--
作者：
Lee, Heon-Jeong;Sung, Seung-Mo;Kim, Leen
背景：季节性情感障碍和情绪和行为的季节性节律(季节性)已被报道与5-羟色胺能系统有关。在本研究中，我们调查了韩国年轻健康人群中5-羟色胺2A受体(5HTR2A)-1438A/G多态与季节变化的关系。对受试者进行5HTR2A-1438A/G基因分型，并用季节性模式评估问卷(SpaQ)评估情绪和行为的季节性变化。结果：3种基因型的SpaQ总分无差异。但季节性和非季节性之间的基因分布有显著差异。冬季型人群中5HTR2A-1438A等位基因频率显著高于非季节性人群(X(2)=6.8，P=0.009；OR=1.79；95%CI，1.15~2.78)。结论：5HTR2A-1438A/G多态可能与朝鲜族人群的季节性有关。(C)2006爱思唯尔B.V.保留所有权利。
Background: Seasonal affective disorder and seasonal rhythms in mood and behavior (seasonality) have been reported to be associated with serotonergic system. In this study we investigated the relationship between the serotonin 2A receptor (5HTR2A) - 1438 A/G polymorphism and seasonal variation in a young Korean healthy population.Methods: 297 young Korean medical students were recruited for this study. They were genotyped for the 5HTR2A - 1438 A/G polymorphism and evaluated the seasonal variation in mood and behavior by the Seasonality Pattern Assessment Questionnaire (SPAQ).Results: The Global Seasonality Score of the SPAQ among three genotypes were not different. However, the comparison between seasonals and non-seasonals showed significant difference in the genotype distribution. The winter-type seasonals showed a significantly higher frequency of the 5HTR2A - 1438 A allele compared with non-seasonals (chi(2) =6.80, p=0.009; OR= 1.79; 95% Cl, 1.15-2.78).Conclusion: These results suggest that the 5HTR2A - 1438 A/G polymorphism is possibly related to seasonality in the Korean population. (c) 2006 Elsevier B.V. All rights reserved.