Anti-viral tetris: modulation of the innate anti-viral immune response by A20.
Anti-viral tetris: modulation of the innate anti-viral immune response by A20.
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DOI：
10.1007/978-1-4939-0398-6_4
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发表时间：
2014
影响因子：
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通讯作者：
Meztli Arguello;Suzanne Paz;C. Ferran;Herwig P. Moll;J. Hiscott
中科院分区：
文献类型：
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作者：
Meztli Arguello;Suzanne Paz;C. Ferran;Herwig P. Moll;J. Hiscott
The A20 protein has emerged as an important negative regulator of Toll like receptor (TLR) and retinoic acid-inducible gene 1 (RIG-I)-mediated anti-viral signaling. A20 functions both as a RING-type E3 ubiquitin ligase and as a de-ubiquitinating enzyme. Nuclear factor kappa B (NF-κB) and interferon regulatory factor (IRF) pathways are targeted by A20 through mechanisms that appear to be both overlapping and distinct, resulting in the downregulation of interferon α/β (IfNα/β) production. This review specifically details the impact of A20 on the cytosolic RIG-I/MDA5 pathway, a process that is less understood than that of NF-κB but is essential for the regulation of the innate immune response to viral infection.
