Contribution of myeloid-derived suppressor cells to tumor-induced immune suppression, angiogenesis, invasion and metastasis
Contribution of myeloid-derived suppressor cells to tumor-induced immune suppression, angiogenesis, invasion and metastasis
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骨髓源性抑制细胞对肿瘤诱导的免疫抑制、血管生成、侵袭和转移的贡献
DOI：
10.1016/s1673-8527(09)60061-8
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发表时间：
2010-07-01
影响因子：
5.9
通讯作者：
Bian, Xiu-Wu
中科院分区：
文献类型：
--
作者：
Ye, Xian-Zong;Yu, Shi-Cang;Bian, Xiu-Wu
越来越多的证据表明，骨髓源性抑制细胞（MDSC）（被称为“未成熟骨髓细胞”或“骨髓抑制细胞”（MSC））在荷瘤小鼠和癌症患者的癌症进展过程中发挥着关键作用。顾名思义，这些细胞源自骨髓，具有抑制免疫反应的巨大潜力。最近的研究表明这些细胞在肿瘤进展中也起着至关重要的作用。 MDSCs可以直接掺入肿瘤内皮。它们还分泌许多促血管生成因子。此外，它们通过诱导基质金属蛋白酶（MMP）、化学引诱剂的产生和创造转移前环境，在癌症侵袭和转移中发挥重要作用。越来越多的证据支持癌症干细胞（CSC）负责肿瘤发生、治疗抵抗、侵袭和转移的观点。在这里，我们假设 CSC 可能“劫持”MDSC 用作替代利基细胞，从而维持干细胞性并增强化疗和放疗抵抗力。直接针对MDSC的对策可能有助于对抗血管生成并预防癌症的侵袭和转移。因此，MDSC的研究对于了解肿瘤进展和提高癌症治疗效果具有重要意义。
Growing evidence suggests that myeloid-derived suppressor cells (MDSCs), which have been named "immature myeloid cells" or "myeloid suppressor cells" (MSCs), play a critical role during the progression of cancer in tumor-bearing mice and cancer patients. As their name implies, these cells are derived from bone marrow and have a tremendous potential to suppress immune responses. Recent studies indicated that these cells also have a crucial role in tumor progression. MDSCs can directly incorporate into tumor endothelium. They secret many pro-angiogenic factors as well. In addition, they play an essential role in cancer invasion and metastasis through inducing the production of matrix metalloproteinases (MMPs), chemoattractants and creating a pre-metastatic environment. Increasing evidence supports the idea that cancer stem cells (CSCs) are responsible for tumorigenesis, resistance to therapies, invasion and metastasis. Here, we hypothesize that CSCs may "hijack" MDSCs for use as alternative niche cells, leading to the maintenance of stemness and enhanced chemo-and radio-therapy resistance. The countermeasure that directly targets to MDSCs may be useful for against angiogenesis and preventing cancer from invasion and metastasis. Therefore, the study of MDSCs is important to understand tumor progression and to enhance the therapeutic efficacy against cancer.