Regional expression of the histamine H2 receptor in adult and developing rat brain
Regional expression of the histamine H2 receptor in adult and developing rat brain
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DOI：
10.1016/s0306-4522(00)00464-4
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发表时间：
2001-01-01
期刊：
影响因子：
3.3
通讯作者：
Panula, P
中科院分区：
文献类型：
--
作者：
Karlstedt, K;Senkas, A;Panula, P
研究了组胺H-2受体在成年和发育大鼠脑中的表达。Northern blot和原位杂交表明，组胺H-2受体信使RNA在成年大鼠脑中广泛表达，且不局限于神经元。H-2受体在成人脑齿状回、海马CA1-CA3亚区、梨状皮质以及一些间脑核如视交叉上核和红核中表达显著。大多数成人脑核显示非常低的H-2受体表达。组胺H-2受体在发育过程中也在中枢神经系统的广泛区域表达，与胚胎第15天中速神经元中组胺的短暂产生相一致。从胚胎第16、17天到出生，皮质板中组胺H-2受体的表达与组胺能纤维进入大脑皮层的发育和发芽一致。组胺H-2受体在成年大鼠脑中的广泛和弥漫性表达表明，H-2受体在许多脑区调节神经元和星形胶质细胞功能的兴奋性，而不是介导靶向细胞间信号。在发育过程中，组胺Hz受体表达见于组胺能纤维的几个目标区域。这可能表明组胺通过H-2受体调节胎儿大脑的发育。(c) 2001年。Elsevier Science Ltd.出版。版权所有。
Histamine H-2 receptor expression was studied in adult and developing rat brain. Northern blot and in situ hybridizations indicated that histamine H-2 receptor messenger RNA expression is widespread and not limited to neurons in the adult rat brain. Prominent H-2 receptor expression in the adult brain was seen in the dentate gyrus, hippocampal subfields CA1-CA3, piriform cortex and in some diencephalic nuclei, e.g. in the suprachiasmatic nucleus and the red nucleus. Most of the adult brain nuclei displayed a very low H-2 receptor expression. Histamine H-2 receptor was also expressed during development in widespread areas of the central nervous system, coinciding with the transient production of histamine in the raphe neurons at embryonic day 15. From embryonic days 16 and 17 until birth, histamine H-2 receptor expression in the cortical plate coincided with the development and sprouting of histaminergic fibers into the cerebral cortex.The widespread and diffuse expression of histamine H-2 receptors in the adult rat brain suggests that the H-2 receptor modulates the excitability of neuron and astrocyte functions in many brain areas rather than mediating targeted cell-to-cell signals. During development, histamine Hz receptor expression is seen in several target areas for the histaminergic fibers. This could indicate that histamine, through the H-2 receptor, regulates fetal development of the brain. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.