Origins of cardiac fibroblasts.
Origins of cardiac fibroblasts.
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DOI：
10.1161/circresaha.110.231910
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发表时间：
2010-11-26
影响因子：
20.1
通讯作者：
Kalluri R
中科院分区：
文献类型：
--
作者：
Zeisberg EM;Kalluri R
心脏成纤维细胞在维持正常心功能中起着至关重要的作用。它们对心肌损伤的损伤控制和组织重塑是不可或缺的，是病理性心脏重塑和纤维化的主要介体。尽管心脏成纤维细胞具有多种功能，但其分子特征仍然很差。越来越多的证据表明，心脏成纤维细胞是一个异质性群体，可能来源于健康和疾病中各种不同的组织生态位。在这里，我们回顾了我们对心脏成纤维细胞来源的新认识，以及我们如何可能利用这一知识来开发治疗心脏纤维化的新疗法。
Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are indispensable for damage control and tissue remodeling on myocardial injury and principal mediators of pathological cardiac remodeling and fibrosis. Despite their manyfold functions, cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is evolving that cardiac fibroblasts are a heterogeneous population and likely derive from various distinct tissue niches in health and disease. Here, we review our emerging understanding of where cardiac fibroblasts come from, as well as how we can possibly use this knowledge to develop novel therapies for cardiac fibrosis.