Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex
Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex
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DOI：
10.1021/ja049378d
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发表时间：
2004-07-21
影响因子：
15
通讯作者：
Goto, M
中科院分区：
文献类型：
--
作者：
Miyako, E;Maruyama, T;Goto, M
我们建立了一种高对映体选择性的光学活性化合物(S)-布洛芬和L-苯丙氨酸的分离体系，通过使用包裹表面活性物质−脂肪酶复合体(或表面活性物质−α-糜蛋白酶复合体)的支撑液膜。在本系统中，包埋在液膜相中的酶有效地驱动光学活性化合物通过SLM的对映选择性传输。这种新型的SLM对布洛芬和苯丙氨酸的光学拆分有很高的对映体选择性(ee超过91%)。
We developed a highly enantioselective separation system for the optically active compounds, (S)-ibuprofen andl-phenylalanine, from their racemic mixtures by employing a supported liquid membrane (SLM) encapsulating a surfactant−lipase complex (or a surfactant−α-chymotrypsin complex). In the present system, enzymes encapsulated in the liquid-membrane phase effectively drove the enantioselective transport of optically active compounds through the SLM. This novel SLM allowed high enantioselectivity (ee over 91%) in the optical resolution of racemic ibuprofen and phenylalanine.