The role of airway epithelial cells and innate immune cells in chronic respiratory disease.
The role of airway epithelial cells and innate immune cells in chronic respiratory disease.
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DOI：
10.1038/nri3739
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发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
Wang X
中科院分区：
文献类型：
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作者：
Holtzman MJ;Byers DE;Alexander-Brett J;Wang X
人们普遍认为，对环境因素的异常免疫反应是导致慢性呼吸道疾病的原因，例如哮喘和慢性阻塞性肺病（COPD）。基于实验模型和人类受试者的研究，越来越多的证据表明先天免疫系统的反应对于此类气道疾病的发展至关重要。气道上皮细胞和先天免疫细胞是慢性气道疾病发病机制的关键组成部分，也是新疗法的新兴靶点。在这篇综述中，我们总结了气道上皮细胞和先天免疫细胞调节慢性呼吸道疾病发展的先天免疫机制。我们还解释了如何在临床上针对这些途径来治疗患有这些疾病的患者。
An abnormal immune response to environmental agents is generally thought to be responsible for causing chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Based on studies of experimental models and human subjects, there is increasing evidence that the response of the innate immune system is crucial for the development of this type of airway disease. Airway epithelial cells and innate immune cells represent key components of the pathogenesis of chronic airway disease and are emerging targets for new therapies. In this Review, we summarize the innate immune mechanisms by which airway epithelial cells and innate immune cells regulate the development of chronic respiratory diseases. We also explain how these pathways are being targeted in the clinic to treat patients with these diseases.