Human epidermal growth factor in gastric carcinoma as a biologic marker of high malignancy.
Human epidermal growth factor in gastric carcinoma as a biologic marker of high malignancy.
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胃癌中人表皮生长因子作为高度恶性肿瘤的生物标志物。
DOI：
10.20772/cancersci1985.77.2_145
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
S. Sakamoto
中科院分区：
文献类型：
--
作者：
E. Tahara;H. Sumiyoshi;J. Hata;W. Yasui;K. Taniyama;Tomonori Hayashi;Shinji Nagae;S. Sakamoto
研究了210例胃癌中人表皮生长因子（hEGF）的存在，其中52例为早期胃癌，113例为晚期胃癌，45例为黏性癌。一项免疫组织化学研究显示，在早期胃癌中没有hegf免疫反应性，而在113例晚期胃癌中有24例（21.2%）检测到hegf阳性肿瘤细胞，在45例硬膜癌中有15例（33.3%）检测到hegf阳性肿瘤细胞。hegf免疫反应在高分化腺癌中的发生率明显高于低分化腺癌（P < 0.05）。42例巩膜低分化腺癌中有13例（30.4%）出现hegf免疫反应性肿瘤细胞，其发生率明显高于非巩膜低分化腺癌（P < 0.05）。免疫组化hEGF阳性肿瘤组织中平均hEGF含量为3.77 +/- 0.61（平均+/- SE） ng/g湿重，hEGF阴性肿瘤组织中平均hEGF含量为2.19 +/- 0.18 ng/g湿重，差异有统计学意义（P < 0.05）。hegf阳性癌（不包括硬膜癌）患者的预后比hegf阴性癌差得多。这些结果表明，肿瘤细胞产生的EGF在胃癌的侵袭性生长和生产性纤维化中起重要作用，也是胃癌患者高恶性程度的生物学标志。
The presence of human epidermal growth factor (hEGF) was studied in a total of 210 gastric carcinomas comprising 52 early carcinomas, 113 advanced carcinomas and 45 scirrhous carcinomas. An immunohistochemical study revealed no hEGF-immunoreactivity in early gastric carcinomas, while hEGF-positive tumor cells were detected in 24 (21.2%) of the 113 advanced carcinomas and in 15 (33.3%) of the 45 scirrhous carcinomas. The incidence of hEGF-immunoreactivity in well-differentiated adenocarcinomas was significantly higher than that in poorly differentiated adenocarcinomas (P less than 0.05). Moreover, hEGF-immunoreactive tumor cells were observed in 13 (30.4%) of the 42 scirrhous poorly differentiated adenocarcinomas, the incidence being significantly higher than that in non-scirrhous poorly differentiated adenocarcinomas (P less than 0.05). The average hEGF content in the tumor tissue estimated by radioimmunoassay was 3.77 +/- 0.61 (mean +/- SE) ng/g wet weight in immunohistochemical hEGF-positive tumors and 2.19 +/- 0.18 ng/g wet weight in hEGF-negative tumors, the difference being significant (P less than 0.05). Patients with hEGF-positive carcinomas (excluding scirrhous carcinomas) had much worse prognosis than those with hEGF-negative carcinomas. These results suggest that EGF produced by tumor cells plays an important role in the invasive growth and productive fibrosis of gastric carcinoma and also serves as a biologic marker of high malignancy in patients with gastric cancers.