Neuropsychological benefits of computerized cognitive rehabilitation training in Ugandan children surviving severe malaria: A randomized controlled trial.
Neuropsychological benefits of computerized cognitive rehabilitation training in Ugandan children surviving severe malaria: A randomized controlled trial.
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计算机认知康复训练对乌干达严重疟疾幸存者的神经心理学益处：一项随机对照试验。
DOI：
10.1016/j.brainresbull.2018.03.002
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发表时间：
2019-03
影响因子：
3.8
通讯作者：
Giordani B
中科院分区：
文献类型：
--
作者：
Boivin MJ;Nakasujja N;Sikorskii A;Ruiseñor-Escudero H;Familiar-Lopez I;Walhof K;van der Lugt EM;Opoka RO;Giordani B
计算机认知康复训练（CCRT）可能有助于减轻乌干达严重疟疾幸存者持续存在的神经认知缺陷。我们完成了一项针对严重疟疾和非疟疾儿童的CCRT随机对照试验。150名学龄严重疟疾儿童和150名非疟疾儿童被随机分为三个治疗组：24次船长日志CCRT训练，用于注意力、工作记忆和非语言推理，其中9项任务的难度随熟练程度的提高而增加；有限的CCRT组没有逐渐达到熟练程度，而是随机地在最简单到中等水平的训练中循环；还有一个被动控制臂。在CCRT干预前后2个月及干预后1年，对儿童进行考夫曼儿童评估量表第二版（kbc - ii）、计算机化CogState认知测试、执行功能行为评定量表（BRIEF）和Achenbach儿童行为检查表（CBCL）的测试。有限ccrt干预组疟疾儿童在kbc - ii心理加工指数（P=0.04）、顺序加工（工作记忆）（P=0.02）和概念思维子测试（计划/推理）（P=0.02）上显著优于被动对照组。在培训后1年，与被动对照相比，有限CCRT疟疾儿童的CogState卡检测（注意力）速度更快（P=0.02）， BRIEF全球执行指数（P=0.01）也有所提高。接受CCRT的非疟疾儿童仅在KABC-II概念思维（全CCRT和有限CCRT均有，P<0.01）、CogState Groton迷宫追赶和学习（P<0.01）和CogState卡片识别（P=0.05，全CCRT）方面获益显著。仅在全ccrt干预组中，非疟疾儿童的KABC-II概念思维计划子测试的改善持续到一年随访。对于严重疟疾幸存者来说，有限的CCRT比完整的CCRT更能改善注意力和记忆结果，这可能是因为在没有完整CCRT的表现滴定的情况下，相关培训任务的重复和练习更多。除了概念思维的计划/推理子测试外，非疟疾儿童的认知和行为方面的显著改善较少，与有限ccrt相比，完全ccrt的改善持续到一年的随访。ClinicalTrials.gov注册号NCT01743417，于2012年9月5日提交
Computerized cognitive rehabilitation training (CCRT) may be beneficial for alleviating persisting neurocognitive deficits in Ugandan severe malaria survivors. We completed a randomized controlled trial of CCRT for both severe malaria and non-malaria cohorts of children. 150 school-age severe malaria and 150 non-malaria children were randomized to three treatment arms: 24 sessions of Captain’s Log CCRT for attention, working memory and nonverbal reasoning, in which training on each of 9 tasks difficulty increased with proficiency; a limited CCRT arm that did not titrate to proficiency but randomly cycled across the simplest to moderate level of training; and a passive control arm. Before and after 2 months of CCRT intervention and one year following, children were tested with the Kaufman Assessment Battery for Children, 2nd edition (KABC-II), computerized CogState cognitive tests, the Behavior Rating Inventory for Executive Function (BRIEF), and the Achenbach Child Behavior Checklist (CBCL). Malaria children assigned to the limited-CCRT intervention arm were significantly better than passive controls on KABC-II Mental Processing Index (P=0.04), Sequential Processing (working memory) (P=0.02) and the Conceptual Thinking subtest (planning/reasoning) (P=0.02). At one year post-training, the limited CCRT malaria children had more rapid CogState card detection (attention) (P=0.02), and improved BRIEF Global Executive Index (P=0.01) as compared to passive controls. Non-malaria children receiving CCRT significantly benefited only on KABC-II Conceptual Thinking (both full- and limited-CCRT; P<0.01), CogState Groton maze chase and learning (P<0.01), and CogState card identification (P=0.05, full CCRT only). Improvements in KABC-II Conceptual Thinking planning subtest for the non-malaria children persisted to one-year follow-up only for the full-CCRT intervention arm. . For severe malaria survivors, limited CCRT improved attention and memory outcomes more than full CCRT, perhaps because of the greater repetition and practice on relevant training tasks in the absence of the performance titration for full CCRT. There were fewer significant cognitive and behavior benefits for the non-malaria children, with the exception of the planning/reasoning subtest of Conceptual Thinking, with stronger full- compared to limited-CCRT improvements persisting to one-year follow-up. ClinicalTrials.gov Identifier NCT01743417, Submitted September 5, 2012
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影响因子：
2.6
作者：
Bangirana P;Allebeck P;Boivin MJ;John CC;Page C;Ehnvall A;Musisi S
通讯作者：
Musisi S
在乌干达学龄儿童中对Cogstate电池进行快速神经认知评估的验证。
影响因子：
5.6
作者：
Bangirana P;Sikorskii A;Giordani B;Nakasujja N;Boivin MJ
通讯作者：
Boivin MJ
影响因子：
3.7
作者：
Bangirana, Paul;John, Chandy C.;Boivin, Michael J.
通讯作者：
Boivin, Michael J.
影响因子：
11.8
作者：
Bangirana, Paul;Opoka, Robert O.;John, Chandy C.
通讯作者：
John, Chandy C.
影响因子：
3.6
作者：
BOIVIN, MJ;GIORDANI, B
通讯作者：
GIORDANI, B