Long-term results of amniotic membrane transplantation-assisted bleb revision for leaking blebs
Long-term results of amniotic membrane transplantation-assisted bleb revision for leaking blebs
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DOI：
10.1007/s00417-007-0727-x
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发表时间：
2008-04
期刊：
影响因子：
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通讯作者：
A. Nagai-Kusuhara;Makoto Nakamura;M. Fujioka;A. Negi
中科院分区：
文献类型：
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作者：
A. Nagai-Kusuhara;Makoto Nakamura;M. Fujioka;A. Negi
BackgroundTo report long-term results of amniotic membrane transplantation（AMT）-assisted bleb review for tuberculosis leak.MethodsRetrospective病历回顾性分析2001年12月至2004年3月期间在科比大学医院接受AMT辅助的滤过泡翻修术治疗迟发性滤过泡渗漏的6例连续患者。所有患者都有辅助使用0.4 mg/ml丝裂霉素C的小梁切除术史。既往小梁切除术与滤过泡渗漏之间的中位（范围）间隔为15（4-54）个月。术前眼压低于10 mmHg者2例，高于25 mmHg者3例，均为局限性缺血性薄壁滤过泡，周围广泛瘢痕组织。AMT辅助滤过泡翻修术后的中位随访时间（范围）为49（41-67）个月。所有未用药或最多使用三种青光眼药物的患者术后IOP均得到良好控制。在整个随访期间，没有患者出现滤过泡漏复发或AMT相关并发症。所有患者在最后一次访视时均显示弥漫性滤过泡向后延伸超出结膜切口line. ConclusionAMT辅助滤过泡翻修成功治疗顽固性迟发性滤过泡渗漏。需要进一步的比较研究来证实目前的结果。
BackgroundTo report long-term results of amniotic membrane transplantation (AMT)-assisted bleb revision for intractable late-onset bleb leak.MethodsRetrospective medical record review of six consecutive patients who underwent AMT-assisted bleb revision for late-onset bleb leak at the Kobe University hospital between December 2001 and March 2004.ResultsThe median (range) of age was 60 (20–77) years. All patients had a history of trabeculectomy with adjunctive use of 0.4 mg/ml mitomycin C. The median (range) of interval between the prior trabeculectomy and bleb leak was 15 (4–54) months. Preoperative intraocular pressure (IOP) was lower than 10 mmHg in two cases, while it was 25 mmHg or higher in three patients, who had a localized, ischemic, thin-wall leaking bleb circumscribed with extensively scarred tissue. The median (range) of follow-up after the AMT-assisted bleb revision was 49 (41–67) months. Postoperative IOP was well controlled in all patients without medication or with a maximum of three glaucoma medications. No patients presented recurrence of the bleb leak or AMT-related complications during entire follow-up. All patients showed at final visit a diffuse bleb which extended posteriorly beyond the conjunctival incision line.ConclusionAMT-assisted bleb revision successfully treated intractable late-onset bleb leak. Further comparative studies are needed to confirm the present result.