Binding of glucuronoxylomannan to the CD14 receptor in human A549 alveolar cells induces interleukin-8 production
Binding of glucuronoxylomannan to the CD14 receptor in human A549 alveolar cells induces interleukin-8 production
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DOI：
10.1128/cvi.00296-06
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发表时间：
2007-01-01
影响因子：
--
通讯作者：
Rodrigues, Marcio L.
中科院分区：
文献类型：
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作者：
Barbosa, Fabiane M.;Fonseca, Fernanda L.;Rodrigues, Marcio L.
葡萄糖醛酸甘露聚糖（GXM）是新生隐球菌的主要荚膜多糖。GXM受体的特点是在吞噬细胞和内皮细胞，但上皮分子识别多糖仍然未知。在目前的研究中，我们证明GXM结合到人II型肺泡上皮细胞中的CD 14受体，导致促炎趋化因子白细胞介素-8的产生。
Glucuronoxylomarman (GXM) is the major capsular polysaccharide of Cryptococcus neoformans. GXM receptors have been characterized in phagocytes and endothelial cells, but epithelial molecules recognizing the polysaccharide remain unknown. In the current study, we demonstrate that GXM binds to the CD14 receptor in human type II alveolar epithelial cells, resulting in the production of the proinflammatory chemokine interleukin-8.